D50-D89141 V28 risk-adjusting codes
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
ICD-10-CM Chapter 3 (D50-D89) in the FY2026 code set. 141 codes in this chapter map to a CMS-HCC V28 payment category, across 11 HCC categories.
CMS-HCC V28 categories in this chapter (11)
Open any category for its full member-code list, RAF, and hierarchy.
- HCC 108 Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major31
- HCC 109 Acquired Hemolytic, Aplastic, and Sideroblastic Anemias30
- HCC 112 Immune Thrombocytopenia and Specified Coagulation Defects and Hemorrhagic Conditions19
- HCC 115 Specified Immunodeficiencies and White Blood Cell Disorders19
- HCC 114 Common Variable and Combined Immunodeficiencies18
- HCC 107 Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero14
- HCC 454 Stem Cell, Including Bone Marrow, Transplant Status/Complications4
- HCC 111 Hemophilia, Male2
- HCC 93 Rheumatoid Arthritis and Other Specified Inflammatory Rheumatic Disorders2
- HCC 19 Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers1
- HCC 387 Pemphigus, Pemphigoid, and Other Specified Autoimmune Skin Disorders1
Risk-adjusting ICD-10-CM codes (141)
Codes in this chapter that map to a CMS-HCC V28 payment category. Open any code for its full detail.
- D56.1Beta thalassemia
- D56.2Delta-beta thalassemia
- D56.5Hemoglobin E-beta thalassemia
- D57.00Hb-SS disease with crisis, unspecified
- D57.01Hb-SS disease with acute chest syndrome
- D57.02Hb-SS disease with splenic sequestration
- D57.03Hb-SS disease with cerebral vascular involvement
- D57.04Hb-SS disease with dactylitis
- D57.09Hb-SS disease with crisis with other specified complication
- D57.1Sickle-cell disease without crisis
- D57.20Sickle-cell/Hb-C disease without crisis
- D57.211Sickle-cell/Hb-C disease with acute chest syndrome
- D57.212Sickle-cell/Hb-C disease with splenic sequestration
- D57.213Sickle-cell/Hb-C disease with cerebral vascular involvement
- D57.214Sickle-cell/Hb-C disease with dactylitis
- D57.218Sickle-cell/Hb-C disease with crisis with other specified complication
- D57.219Sickle-cell/Hb-C disease with crisis, unspecified
- D57.40Sickle-cell thalassemia without crisis
- D57.411Sickle-cell thalassemia, unspecified, with acute chest syndrome
- D57.412Sickle-cell thalassemia, unspecified, with splenic sequestration
- D57.413Sickle-cell thalassemia, unspecified, with cerebral vascular involvement
- D57.414Sickle-cell thalassemia, unspecified, with dactylitis
- D57.418Sickle-cell thalassemia, unspecified, with crisis with other specified complication
- D57.419Sickle-cell thalassemia, unspecified, with crisis
- D57.42Sickle-cell thalassemia beta zero without crisis
- D57.431Sickle-cell thalassemia beta zero with acute chest syndrome
- D57.432Sickle-cell thalassemia beta zero with splenic sequestration
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvement
- D57.434Sickle-cell thalassemia beta zero with dactylitis
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complication
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecified
- D57.44Sickle-cell thalassemia beta plus without crisis
- D57.451Sickle-cell thalassemia beta plus with acute chest syndrome
- D57.452Sickle-cell thalassemia beta plus with splenic sequestration
- D57.453Sickle-cell thalassemia beta plus with cerebral vascular involvement
- D57.454Sickle-cell thalassemia beta plus with dactylitis
- D57.458Sickle-cell thalassemia beta plus with crisis with other specified complication
- D57.459Sickle-cell thalassemia beta plus with crisis, unspecified
- D57.80Other sickle-cell disorders without crisis
- D57.811Other sickle-cell disorders with acute chest syndrome
- D57.812Other sickle-cell disorders with splenic sequestration
- D57.813Other sickle-cell disorders with cerebral vascular involvement
- D57.814Other sickle-cell disorders with dactylitis
- D57.818Other sickle-cell disorders with crisis with other specified complication
- D57.819Other sickle-cell disorders with crisis, unspecified
- D59.10Autoimmune hemolytic anemia, unspecified
- D59.11Warm autoimmune hemolytic anemia
- D59.12Cold autoimmune hemolytic anemia
- D59.13Mixed type autoimmune hemolytic anemia
- D59.19Other autoimmune hemolytic anemia
- D59.30Hemolytic-uremic syndrome, unspecified
- D59.31Infection-associated hemolytic-uremic syndrome
- D59.32Hereditary hemolytic-uremic syndrome
- D59.39Other hemolytic-uremic syndrome
- D59.4Other nonautoimmune hemolytic anemias
- D59.5Paroxysmal nocturnal hemoglobinuria [Marchiafava-Micheli]
- D59.6Hemoglobinuria due to hemolysis from other external causes
- D59.8Other acquired hemolytic anemias
- D59.9Acquired hemolytic anemia, unspecified
- D60.0Chronic acquired pure red cell aplasia
- D60.8Other acquired pure red cell aplasias
- D60.9Acquired pure red cell aplasia, unspecified
- D61.01Constitutional (pure) red blood cell aplasia
- D61.02Shwachman-Diamond syndrome
- D61.03Fanconi anemia
- D61.09Other constitutional aplastic anemia
- D61.2Aplastic anemia due to other external agents
- D61.3Idiopathic aplastic anemia
- D61.818Other pancytopenia
- D61.82Myelophthisis
- D61.89Other specified aplastic anemias and other bone marrow failure syndromes
- D64.0Hereditary sideroblastic anemia
- D64.1Secondary sideroblastic anemia due to disease
- D64.3Other sideroblastic anemias
- D64.4Congenital dyserythropoietic anemia
- D66Hereditary factor VIII deficiency
- D67Hereditary factor IX deficiency
- D68.00Von Willebrand disease, unspecified
- D68.01Von Willebrand disease, type 1
- D68.020Von Willebrand disease, type 2A
- D68.021Von Willebrand disease, type 2B
- D68.022Von Willebrand disease, type 2M
- D68.023Von Willebrand disease, type 2N
- D68.029Von Willebrand disease, type 2, unspecified
- D68.03Von Willebrand disease, type 3
- D68.04Acquired von Willebrand disease
- D68.09Other von Willebrand disease
- D68.1Hereditary factor XI deficiency
- D68.2Hereditary deficiency of other clotting factors
- D68.311Acquired hemophilia
- D69.1Qualitative platelet defects
- D69.3Immune thrombocytopenic purpura
- D69.41Evans syndrome
- D69.42Congenital and hereditary thrombocytopenia purpura
- D69.49Other primary thrombocytopenia
- D70.0Congenital agranulocytosis
- D70.4Cyclic neutropenia
- D71Functional disorders of polymorphonuclear neutrophils
- D71.1Leukocyte adhesion deficiency
- D71.8Other functional disorders of polymorphonuclear neutrophils
- D71.9Functional disorders of polymorphonuclear neutrophils, unspecified
- D72.0Genetic anomalies of leukocytes
- D75.81Myelofibrosis
- D75.84Other platelet-activating anti-PF4 disorders
- D76.1Hemophagocytic lymphohistiocytosis
- D76.3Other histiocytosis syndromes
- D80.0Hereditary hypogammaglobulinemia
- D80.2Selective deficiency of immunoglobulin A [IgA]
- D80.3Selective deficiency of immunoglobulin G [IgG] subclasses
- D80.4Selective deficiency of immunoglobulin M [IgM]
- D80.5Immunodeficiency with increased immunoglobulin M [IgM]
- D81.0Severe combined immunodeficiency [SCID] with reticular dysgenesis
- D81.1Severe combined immunodeficiency [SCID] with low T- and B-cell numbers
- D81.2Severe combined immunodeficiency [SCID] with low or normal B-cell numbers
- D81.30Adenosine deaminase deficiency, unspecified
- D81.31Severe combined immunodeficiency due to adenosine deaminase deficiency
- D81.32Adenosine deaminase 2 deficiency
- D81.39Other adenosine deaminase deficiency
- D81.4Nezelof's syndrome
- D81.5Purine nucleoside phosphorylase [PNP] deficiency
- D81.6Major histocompatibility complex class I deficiency
- D81.7Major histocompatibility complex class II deficiency
- D81.82Activated Phosphoinositide 3-kinase Delta Syndrome [APDS]
- D81.89Other combined immunodeficiencies
- D81.9Combined immunodeficiency, unspecified
- D82.0Wiskott-Aldrich syndrome
- D82.1Di George's syndrome
- D83.0Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function
- D83.1Common variable immunodeficiency with predominant immunoregulatory T-cell disorders
- D83.2Common variable immunodeficiency with autoantibodies to B- or T-cells
- D83.8Other common variable immunodeficiencies
- D83.9Common variable immunodeficiency, unspecified
- D84.1Defects in the complement system
- D86.3Sarcoidosis of skin
- D86.86Sarcoid arthropathy
- D86.87Sarcoid myositis
- D89.810Acute graft-versus-host disease
- D89.811Chronic graft-versus-host disease
- D89.812Acute on chronic graft-versus-host disease
- D89.813Graft-versus-host disease, unspecified
- D89.84IgG4-related disease
Frequently asked questions
How many ICD-10-CM codes in Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism risk-adjust under CMS-HCC V28?
141 ICD-10-CM codes in the D50-D89 chapter (Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism) map to a CMS-HCC V28 payment category for payment year 2026.
Which CMS-HCC V28 categories do D50-D89 codes map to?
Codes in this chapter map to 11 distinct CMS-HCC V28 categories, most commonly HCC 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major), HCC 109 (Acquired Hemolytic, Aplastic, and Sideroblastic Anemias), HCC 112 (Immune Thrombocytopenia and Specified Coagulation Defects and Hemorrhagic Conditions).
What ICD-10-CM chapter is D50-D89?
D50-D89 is ICD-10-CM Chapter 3, Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism, in the FY2026 code set.
Source: FY2026 ICD-10-CM Tabular (CDC/NCHS) and the CMS-HCC v28 PY2026 mapping file.