D57.418

HCC Category Mapping

What This Code Means

A combination blood disorder mixing sickle-cell disease and thalassemia that causes a crisis with additional complications beyond the typical sickle-cell crisis symptoms.

Coding Tips

• •Ensure documentation specifies the exact complication beyond standard crisis (e.g., infection, organ damage) to justify the 'other specified' designation
• •Verify the thalassemia type is unspecified before assigning this code; if beta-zero or beta-plus is documented, use the more specific codes D57.43x or D57.45x

Clinical Significance

This code captures sickle-cell thalassemia (unspecified type) crises with specified complications not classified under acute chest syndrome, splenic sequestration, cerebral vascular involvement, or dactylitis. These may include priapism, hepatic sequestration, aplastic crisis, renal crisis, or other organ-specific vaso-occlusive events in patients whose thalassemia subtype (beta-zero vs. beta-plus) is undocumented.

Documentation Requirements

• ✓Documentation must confirm the sickle-cell thalassemia genotype, identify the specific crisis complication, and query for beta-zero vs.
• ✓beta-plus specification.
• ✓The provider should describe the complication type, clinical presentation, diagnostic findings, treatment, and outcome.
• ✓Document why the complication does not fit D57.411-D57.414 categories.

Commonly Confused Codes