D59.39

HCC Category Mapping

What This Code Means

Hemolytic-uremic syndrome caused by factors other than infection or heredity, such as certain medications or conditions.

Coding Tips

• •Document the specific cause of HUS when identifiable (e.g., medication, malignancy, or other trigger)
• •Differentiate from infection-associated and hereditary forms to ensure accurate coding

Clinical Significance

Other hemolytic-uremic syndrome captures cases of thrombotic microangiopathy with the hemolytic-uremic syndrome triad caused by factors other than infection or hereditary complement defects. Common causes include medications (calcineurin inhibitors, gemcitabine, quinine, bevacizumab), malignant hypertension, transplant-associated thrombotic microangiopathy, pregnancy-related conditions, and autoimmune diseases. Identifying the specific trigger is essential because treatment depends on removing the causative factor rather than complement inhibition or supportive care alone.

Documentation Requirements

• ✓Document the specific causative factor or trigger for hemolytic-uremic syndrome (drug, underlying condition, or exposure).
• ✓Record the triad findings with supporting laboratory values including schistocytes on peripheral smear.
• ✓Include ADAMTS13 activity level to exclude thrombotic thrombocytopenic purpura.
• ✓Document complement testing results to exclude hereditary forms.
• ✓Record treatment directed at the underlying cause and any supportive measures including dialysis or plasma exchange.

Commonly Confused Codes