FY2027 ICD-10-CM reference
T50: Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances
By the HCC Buddy Coding Team
The official ICD-10-CM descriptor is Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Nonbillable heading. Verified against the official FY2027 order file.
More specific FY2027 codes
- T50.0: Poisoning by, adverse effect of and underdosing of mineralocorticoids and their antagonistsNonbillable heading
- T50.1: Poisoning by, adverse effect of and underdosing of loop [high-ceiling] diureticsNonbillable heading
- T50.2: Poisoning by, adverse effect of and underdosing of carbonic-anhydrase inhibitors, benzothiadiazides and other diureticsNonbillable heading
- T50.3: Poisoning by, adverse effect of and underdosing of electrolytic, caloric and water-balance agentsNonbillable heading
- T50.4: Poisoning by, adverse effect of and underdosing of drugs affecting uric acid metabolismNonbillable heading
- T50.5: Poisoning by, adverse effect of and underdosing of appetite depressantsNonbillable heading
- T50.6: Poisoning by, adverse effect of and underdosing of antidotes and chelating agentsNonbillable heading
- T50.7: Poisoning by, adverse effect of and underdosing of analeptics and opioid receptor antagonistsNonbillable heading
- T50.8: Poisoning by, adverse effect of and underdosing of diagnostic agentsNonbillable heading
- T50.A: Poisoning by, adverse effect of and underdosing of bacterial vaccinesNonbillable heading
- T50.B: Poisoning by, adverse effect of and underdosing of viral vaccinesNonbillable heading
- T50.Z: Poisoning by, adverse effect of and underdosing of other vaccines and biological substancesNonbillable heading
- T50.9: Poisoning by, adverse effect of and underdosing of other and unspecified drugs, medicaments and biological substancesNonbillable heading
FY2027 Tabular instructions
Instructions below include applicable chapter, section and parent-code notes. Each note identifies where it appears in the official source.
Instructional note
Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
Source: S00-T88 (chapter, inherited).
Instructional note
code to identify any retained foreign body, if applicable (Z18.-)
Source: S00-T88 (chapter, inherited).
Excludes2
birth trauma (P10-P15)
Source: S00-T88 (chapter, inherited).
Excludes2
obstetric trauma (O70-O71)
Source: S00-T88 (chapter, inherited).
Instructional note
The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.
Source: S00-T88 (chapter, inherited).
Includes
adverse effect of correct substance properly administered
Source: T36-T50 (section, inherited).
Includes
poisoning by overdose of substance
Source: T36-T50 (section, inherited).
Includes
poisoning by wrong substance given or taken in error
Source: T36-T50 (section, inherited).
Includes
underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed
Source: T36-T50 (section, inherited).
Code first
, for adverse effects, the nature of the adverse effect, such as:
Source: T36-T50 (section, inherited).
Code first
adverse effect NOS (T88.7)
Source: T36-T50 (section, inherited).
Code first
aspirin gastritis (K29.-)
Source: T36-T50 (section, inherited).
Code first
blood disorders (D56-D76)
Source: T36-T50 (section, inherited).
Code first
contact dermatitis (L23-L25)
Source: T36-T50 (section, inherited).
Code first
dermatitis due to substances taken internally (L27.-)
Source: T36-T50 (section, inherited).
Code first
nephropathy (N14.0-N14.2)
Source: T36-T50 (section, inherited).
Instructional note
The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.
Source: T36-T50 (section, inherited).
Instructional note
code(s) to specify:
Source: T36-T50 (section, inherited).
Instructional note
manifestations of poisoning
Source: T36-T50 (section, inherited).
Instructional note
underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
Source: T36-T50 (section, inherited).
Instructional note
underdosing of medication regimen (Z91.12-, Z91.13-)
Source: T36-T50 (section, inherited).
Excludes1
toxic reaction to local anesthesia in pregnancy (O29.3-)
Source: T36-T50 (section, inherited).
Excludes2
abuse and dependence of psychoactive substances (F10-F19)
Source: T36-T50 (section, inherited).
Excludes2
abuse of non-dependence-producing substances (F55.-)
Source: T36-T50 (section, inherited).
Excludes2
immunodeficiency due to drugs (D84.821)
Source: T36-T50 (section, inherited).
Excludes2
drug reaction and poisoning affecting newborn (P00-P96)
Source: T36-T50 (section, inherited).
Excludes2
pathological drug intoxication (inebriation) (F10-F19)
Source: T36-T50 (section, inherited).
Seventh-character instruction
The appropriate 7th character is to be added to each code from category T50
Source: T50 (category, direct).
Instructional note
initial encounter
Source: T50 (category, direct).
Instructional note
subsequent encounter
Source: T50 (category, direct).
Instructional note
sequela
Source: T50 (category, direct).
Seventh-character definitions
- A: initial encounter
- D: subsequent encounter
- S: sequela
Compare the FY2027 additions, removals and billable-status changes
What does T50 mean in FY2027?
The official ICD-10-CM descriptor is Poisoning by, adverse effect of and underdosing of diuretics and other and unspecified drugs, medicaments and biological substances. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Is T50 billable in FY2027?
The FY2027 order file marks T50 as a nonbillable heading. Select a complete billable child code.
Does T50 map to an HCC?
Risk-model mapping is not applicable to this nonbillable heading. Check a complete billable child code.
Source: CMS FY2027 ICD-10-CM order file. Payment model: CMS CY 2027 Rate Announcement. Read the FY2027 Official Guidelines.
Review the FY2026 April edition
