D57.453 ICD-10-CM Code: Sickle-cell thalassemia beta plus with cerebral vascular involvement
D57.453 maps to CMS-HCC V28 108. A source-labeled RAF reference is available. Confirm the documented diagnosis and applicable coding requirements. MEAT criteria · RAF Calculator · HCC Buddy coding tools
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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Hemolytic anemias (D55-D59)
D57.453
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceSickle-cell thalassemia beta plus with cerebral vascular involvement
A blood disorder combining sickle-cell disease and thalassemia that causes stroke or blood vessel problems in the brain.
Buddy Insight
Cerebral vascular involvement in sickle-cell thalassemia beta plus is less common than in Hemoglobin SS or beta-zero genotypes due to the milder disease phenotype, but it can still occur with devastating consequences.
CMS-HCC V28
MappedHCC 108
Code-level coefficient reference
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 071
Code-level coefficient reference
ESRD/PACE
MappedHCC 46
Code-level coefficient reference
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- HbS-beta plus with cerebral vascular involvement
- Sickle-cell beta plus with cerebral vascular involvement
- Sickle-cell beta thalassemiaInherited from D57.4, D57.45
- Thalassemia Hb-S diseaseInherited from D57.4, D57.45
- HbS-beta plus with crisisInherited from D57.4, D57.45
- Sickle-cell beta plus with crisisInherited from D57.4, D57.45
Excludes 2
Official- autoimmune disease (systemic) NOS (M35.9)Inherited from D50-D89
- certain conditions originating in the perinatal period (P00-P96)Inherited from D50-D89
- complications of pregnancy, childbirth and the puerperium (O00-O9A)Inherited from D50-D89
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Inherited from D50-D89
- endocrine, nutritional and metabolic diseases (E00-E88)Inherited from D50-D89
- human immunodeficiency virus [HIV] disease (B20)Inherited from D50-D89
- injury, poisoning and certain other consequences of external causes (S00-T88)Inherited from D50-D89
- neoplasms (C00-D49)Inherited from D50-D89
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)Inherited from D50-D89
Related Codes
Includes
OfficialNo Includes notes are included in this display for D57.453. Check the code and parent instructions in the Code Book.
Excludes 1
Official- other hemoglobinopathies (D58.-)Inherited from D57
Code First
OfficialNo Code First sequencing instructions are included in this display for D57.453. Check the code and parent instructions in the Code Book.
Use Additional
Official- code for any associated fever (R50.81)Inherited from D57
Code Also
Official- , if applicable cerebral infarction (I63.-)
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is D57.453 an HCC code?
Yes. D57.453 (Sickle-cell thalassemia beta plus with cerebral vascular involvement) maps to HCC 108, Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 0.146. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.
Coder answer: D57.453 is billable and maps to V28 HCC 108, Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- D57.453
- Description
- Sickle-cell thalassemia beta plus with cerebral vascular involvement
- HCC (V28)
- HCC 108 — Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major
- RAF reference coefficient
- 0.146
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work D57.453 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT review for D57.453
For D57.453, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Coder workflow notes
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What This Code Means
D57.453 is the ICD-10-CM diagnosis code for sickle-cell thalassemia beta plus with cerebral vascular involvement. A blood disorder combining sickle-cell disease and thalassemia that causes stroke or blood vessel problems in the brain. D57.453 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering hemolytic anemias (d55-d59).
Under the CMS-HCC V28 risk adjustment model, D57.453 maps to Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major (HCC 108) with a source-labeled community, non-dual, aged reference coefficient of 0.146. No V24 mapping is shown for D57.453; use the applicable model and payment year when reviewing the V28 mapping. For CY2026 non-PACE Medicare Advantage, CMS uses 100% of the 2024 CMS-HCC model (V28). PACE uses a separate model blend. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.
This code indicates a serious complication affecting cerebral blood vessels; ensure documentation clearly supports the cerebral vascular involvement. For D57.453, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for D57.453 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •This code indicates a serious complication affecting cerebral blood vessels; ensure documentation clearly supports the cerebral vascular involvement
- •Verify the specific type of sickle-cell thalassemia (beta plus) is documented before assigning this code
Clinical Significance
Cerebral vascular involvement in sickle-cell thalassemia beta plus is less common than in Hemoglobin SS or beta-zero genotypes due to the milder disease phenotype, but it can still occur with devastating consequences. The higher baseline hemoglobin in beta-plus patients may contribute to hyperviscosity-related cerebrovascular events, particularly during dehydration or acute illness. Stroke prevention screening protocols should still be followed.
Documentation Requirements
- ✓Documentation must confirm sickle-cell thalassemia beta plus genotype and the cerebrovascular event with neurological examination and neuroimaging results.
- ✓Record the stroke type, neurological deficits, treatment (exchange transfusion targeting Hemoglobin S reduction), and follow-up plan including chronic transfusion therapy consideration and neurological rehabilitation.
- ✓Document transcranial Doppler velocities if available.
Code Also
- , if applicable cerebral infarction (I63.-)
Commonly Confused Codes
- •D57.453 vs. D57.433 (Beta zero with cerebral vascular involvement) -
- •beta-zero has higher stroke risk and higher HCC mapping. D57.453 vs. D57.413 (Unspecified with cerebral vascular involvement) -
- •D57.453 specifies beta-plus. D57.453 vs. D57.03 (Hemoglobin SS with cerebral vascular involvement) -
- •different genotype.