D57.452 ICD-10-CM Code: Sickle-cell thalassemia beta plus with splenic sequestration
D57.452 maps to CMS-HCC V28 108. A source-labeled RAF reference is available. Confirm the documented diagnosis and applicable coding requirements. MEAT criteria · RAF Calculator · free HCC coding tools
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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Hemolytic anemias (D55-D59)
D57.452
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceSickle-cell thalassemia beta plus with splenic sequestration
A combination blood disorder with sickle-cell and thalassemia beta-plus causing splenic sequestration, where blood becomes trapped in the spleen leading to anemia and spleen enlargement.
Buddy Insight
Splenic sequestration in sickle-cell thalassemia beta plus is notable because beta-plus patients are more likely to retain splenic function into adulthood compared to Hemoglobin SS or beta-zero patients, maintaining the risk of this potentially fatal complication throughout life.
CMS-HCC V28
MappedHCC 108
Code-level coefficient reference
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
MappedHCC 071
Code-level coefficient reference
ESRD/PACE
MappedHCC 46
Code-level coefficient reference
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- HbS-beta plus with splenic sequestration
- Sickle-cell beta plus with splenic sequestration
- Sickle-cell beta thalassemiaInherited from D57.4, D57.45
- Thalassemia Hb-S diseaseInherited from D57.4, D57.45
- HbS-beta plus with crisisInherited from D57.4, D57.45
- Sickle-cell beta plus with crisisInherited from D57.4, D57.45
Excludes 2
Official- autoimmune disease (systemic) NOS (M35.9)Inherited from D50-D89
- certain conditions originating in the perinatal period (P00-P96)Inherited from D50-D89
- complications of pregnancy, childbirth and the puerperium (O00-O9A)Inherited from D50-D89
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Inherited from D50-D89
- endocrine, nutritional and metabolic diseases (E00-E88)Inherited from D50-D89
- human immunodeficiency virus [HIV] disease (B20)Inherited from D50-D89
- injury, poisoning and certain other consequences of external causes (S00-T88)Inherited from D50-D89
- neoplasms (C00-D49)Inherited from D50-D89
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)Inherited from D50-D89
Related Codes
Includes
OfficialNo Includes notes are included in this display for D57.452. Check the code and parent instructions in the Code Book.
Excludes 1
Official- other hemoglobinopathies (D58.-)Inherited from D57
Code First
OfficialNo Code First sequencing instructions are included in this display for D57.452. Check the code and parent instructions in the Code Book.
Use Additional
Official- code for any associated fever (R50.81)Inherited from D57
Code Also
OfficialNo Code Also instructions are included in this display for D57.452. Check the code and parent instructions in the Code Book.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is D57.452 an HCC code?
Yes. D57.452 (Sickle-cell thalassemia beta plus with splenic sequestration) maps to HCC 108, Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major under the CMS-HCC V28 risk adjustment model, with a source-labeled community non-dual aged reference coefficient of 0.146. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes. It is billable for payment year 2026.
Coder answer: D57.452 is billable and maps to V28 HCC 108, Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- D57.452
- Description
- Sickle-cell thalassemia beta plus with splenic sequestration
- HCC (V28)
- HCC 108 — Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major
- RAF reference coefficient
- 0.146
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.
Work D57.452 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →
MEAT review for D57.452
For D57.452, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Coder workflow notes
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What This Code Means
D57.452 is the ICD-10-CM diagnosis code for sickle-cell thalassemia beta plus with splenic sequestration. A combination blood disorder with sickle-cell and thalassemia beta-plus causing splenic sequestration, where blood becomes trapped in the spleen leading to anemia and spleen enlargement. D57.452 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering hemolytic anemias (d55-d59).
Under the CMS-HCC V28 risk adjustment model, D57.452 maps to Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major (HCC 108) with a source-labeled community, non-dual, aged reference coefficient of 0.146. No V24 mapping is shown for D57.452; use the applicable model and payment year when reviewing the V28 mapping. For CY2026 non-PACE Medicare Advantage, CMS uses 100% of the 2024 CMS-HCC model (V28). PACE uses a separate model blend. Source-labeled code-level coefficients are references, not member totals. Actual contribution depends on complete member context, hierarchy and cleanup rules, interactions, and model year. HCC Buddy's RAF Calculator supports CMS-HCC V28 PY2026 and shows no score unless every required source and calculation check passes.
Document evidence of splenic sequestration such as splenomegaly, acute anemia, reticulocytosis, and hemoglobin drop. For D57.452, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for D57.452 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Document evidence of splenic sequestration such as splenomegaly, acute anemia, reticulocytosis, and hemoglobin drop
- •This is a medical emergency requiring possible transfusion; ensure acute presentation is clearly documented
Clinical Significance
Splenic sequestration in sickle-cell thalassemia beta plus is notable because beta-plus patients are more likely to retain splenic function into adulthood compared to Hemoglobin SS or beta-zero patients, maintaining the risk of this potentially fatal complication throughout life. The preserved spleen in beta-plus patients means splenic sequestration crises can occur at any age, unlike Hemoglobin SS where autosplenectomy typically occurs by age 5-8.
Documentation Requirements
- ✓Documentation must confirm sickle-cell thalassemia beta plus genotype and acute splenic sequestration with rapid splenic enlargement and hemoglobin decline.
- ✓Record splenic size, hemoglobin trend, reticulocyte count, platelet count, treatment, and hemodynamic status.
- ✓Document splenic function status and note the lifelong risk in this genotype.
- ✓Record whether splenectomy is recommended.
Commonly Confused Codes
- •D57.452 vs. D57.432 (Beta zero with splenic sequestration) -
- •different thalassemia type. D57.452 vs. D57.412 (Unspecified with splenic sequestration) -
- •D57.452 specifies beta-plus. D57.452 vs. D57.212 (Hemoglobin SC with splenic sequestration) -
- •different genotype but similar lifetime splenic risk.