FY2027 ICD-10-CM reference
D57.458: Sickle-cell thalassemia beta plus with crisis with other specified complication
By the HCC Buddy Coding Team
The official ICD-10-CM descriptor is Sickle-cell thalassemia beta plus with crisis with other specified complication. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Billable code. Verified against the official FY2027 order file.
FY2027 Tabular instructions
Instructions below include applicable chapter, section and parent-code notes. Each note identifies where it appears in the official source.
Excludes2
autoimmune disease (systemic) NOS (M35.9)
Source: D50-D89 (chapter, inherited).
Excludes2
certain conditions originating in the perinatal period (P00-P96)
Source: D50-D89 (chapter, inherited).
Excludes2
complications of pregnancy, childbirth and the puerperium (O00-O9A)
Source: D50-D89 (chapter, inherited).
Excludes2
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
Source: D50-D89 (chapter, inherited).
Excludes2
endocrine, nutritional and metabolic diseases (E00-E88)
Source: D50-D89 (chapter, inherited).
Excludes2
human immunodeficiency virus [HIV] disease (B20)
Source: D50-D89 (chapter, inherited).
Excludes2
injury, poisoning and certain other consequences of external causes (S00-T88)
Source: D50-D89 (chapter, inherited).
Excludes2
neoplasms (C00-D49)
Source: D50-D89 (chapter, inherited).
Excludes2
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: D50-D89 (chapter, inherited).
Instructional note
code for any associated fever (R50.81)
Source: D57 (category, inherited).
Excludes1
other hemoglobinopathies (D58.-)
Source: D57 (category, inherited).
Instructional note
Sickle-cell beta thalassemia
Source: D57.4 (self, inherited).
Instructional note
Thalassemia Hb-S disease
Source: D57.4 (self, inherited).
Instructional note
HbS-beta plus with crisis
Source: D57.45 (self, inherited).
Instructional note
Sickle-cell beta plus with crisis
Source: D57.45 (self, inherited).
Instructional note
HbS-beta plus with crisis with other specified complication
Source: D57.458 (self, direct).
Instructional note
Sickle-cell beta plus with crisis with other specified complication
Source: D57.458 (self, direct).
Instructional note
code to identify complications, such as:
Source: D57.458 (self, direct).
Instructional note
cholelithiasis (K80.-)
Source: D57.458 (self, direct).
Instructional note
priapism (N48.32)
Source: D57.458 (self, direct).
Compare the FY2027 additions, removals and billable-status changes
What does D57.458 mean in FY2027?
The official ICD-10-CM descriptor is Sickle-cell thalassemia beta plus with crisis with other specified complication. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Is D57.458 billable in FY2027?
The FY2027 order file marks D57.458 as billable. Check the complete Tabular instructions and documentation before assigning it.
Does D57.458 map to an HCC?
In the CMS 2027 Initial ICD-10-CM Mappings (payment year 2027, 2026 dates of service), D57.458 maps to CMS-HCC V28 HCC 108 (Sickle Cell Disorders, Except Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero; Beta Thalassemia Major). For 2027 dates of service, CMS has not yet published the payment year 2028 mappings. ESRD, RxHCC, PACE and HHS-HCC mappings are still pending verification for FY2027.
Source: CMS FY2027 ICD-10-CM order file. Read the FY2027 Official Guidelines.
Review the FY2026 April edition