D60.0

Billable

Chronic acquired pure red cell aplasia

HCC Category Mapping

V28HCC 109 — Hemolytic and Aplastic Anemias

0.291

V24HCC 46 — Severe Hematological Disorders

0.666

ESRDHCC 46 — Severe Hematological Disorders

0.000

RxHCCHCC 96 — Hemolytic and Aplastic Anemias

0.000

What This Code Means

A long-term condition where the bone marrow fails to produce red blood cells while other blood cell production remains normal.

Coding Tips

•This code indicates a chronic/persistent condition; document the duration and any treatment responses in the medical record
•Distinguish from transient forms (D60.1) by confirming the condition has lasted more than a few weeks

Clinical Significance

Chronic acquired pure red cell aplasia is a rare hematological condition where the bone marrow selectively fails to produce red blood cell precursors while maintaining normal white blood cell and platelet production. The chronic designation indicates persistence beyond weeks to months, distinguishing it from transient forms. Common associations include thymoma (up to 50% of cases), autoimmune disorders, lymphoproliferative diseases, and parvovirus B19 persistence in immunocompromised patients. Patients typically present with severe normocytic anemia with absent reticulocytes.

Documentation Requirements

✓Document bone marrow biopsy findings showing absent or near-absent erythroid precursors with preserved myeloid and megakaryocytic lineages.
✓Record hemoglobin levels, reticulocyte count (characteristically near zero), and normal white blood cell and platelet counts.
✓Include workup for underlying causes: computed tomography chest for thymoma, parvovirus B19 testing, autoimmune serologies, and lymphoproliferative disease screening.
✓Document treatment response to immunosuppressive therapy, erythropoietin, or thymectomy if applicable.

Commonly Confused Codes

D60.1 (Transient acquired pure red cell aplasia) is for temporary episodes resolving within weeks.D60.9 (Acquired pure red cell aplasia, unspecified) does not specify chronicity.D61.01 (Constitutional pure red blood cell aplasia) also known as Diamond-Blackfan anemia is congenital, not acquired.D61.9 (Aplastic anemia, unspecified) involves all cell lines, not isolated red cell failure.

Code Hierarchy

└D60Acquired pure red cell aplasia [erythroblastopenia]└D60.0Chronic acquired pure red cell aplasia

└D60.0Chronic acquired pure red cell aplasia