What is ICD-10 code D60.1?

D60.1 is the ICD-10-CM diagnosis code for Transient acquired pure red cell aplasia. A temporary condition where the bone marrow temporarily stops producing red blood cells, usually resolving on its own within weeks. D60.1 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. D60.1 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. D60.1 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. D60.1 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for D60.1?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. D60.1 was a payment HCC under V24 (Severe Hematological Disorders) but the V28 recalibration removed it from the risk adjustment model. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting D60.1?

Verify documentation confirms the temporary nature and expected resolution of the condition If the condition persists beyond the expected timeframe, consider recoding to D60.0 or D60.9 Because D60.1 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

D60.1: Transient acquired pure red cell aplasia — ICD-10 | Severe Hematological Disorders

ICD-10-CM Code View

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Code lookupD60.1Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Aplastic and other anemias and other bone marrow failure syndromes (D60-D64)

D60.1

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Transient acquired pure red cell aplasia

A temporary condition where the bone marrow temporarily stops producing red blood cells, usually resolving on its own within weeks.

Buddy Insight

Transient acquired pure red cell aplasia is a temporary cessation of red blood cell production by the bone marrow that typically resolves spontaneously within weeks.

CMS-HCC V28

Not risk-adjusted for this model/period.

RAF 0

CMS-HCC V24

Mapped

HCC 46

Severe Hematological Disorders

RAF 0.666

ACA/HHS

Not risk-adjusted for this model/period.

RAF 0

ESRD/PACE

Mapped

HCC 46

Severe Hematological Disorders

RAF 0.0

RXHCC

Mapped

HCC 96

Hemolytic and Aplastic Anemias

RAF 0.0

Code Trumping

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Code Book Path

Official

D60Acquired pure red cell aplasia [erythroblastopenia]

D60.1Transient acquired pure red cell aplasia

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for D60.1 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for D60.1 in this effective period.

Related Child Codes

Official

D60.0Chronic acquired pure red cell aplasia

D60.8Other acquired pure red cell aplasias

D60.9Acquired pure red cell aplasia, unspecified

Includes

Official

red cell aplasia (acquired) (adult) (with thymoma)

Excludes 1

Official

congenital red cell aplasia (D61.01)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for D60.1 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for D60.1 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for D60.1 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Document the temporary nature of the red cell aplasia with expected or actual resolution timeline.

Record parvovirus B19 serologies (immunoglobulin M for acute infection) or polymerase chain reaction when infection-associated.

Include hemoglobin values, reticulocyte count showing near-zero production, and normal white blood cell and platelet counts.

Document any causative agent or triggering event.

MEAT Support

HCC Buddy guidance

Document the temporary nature of the red cell aplasia with expected or actual resolution timeline.

Record parvovirus B19 serologies (immunoglobulin M for acute infection) or polymerase chain reaction when infection-associated.

Include hemoglobin values, reticulocyte count showing near-zero production, and normal white blood cell and platelet counts.

Document any causative agent or triggering event.

Audit Caution

HCC Buddy guidance

If the condition persists beyond the expected transient period (typically several weeks), reconsider the diagnosis and potentially recode to D60.0 (chronic). When parvovirus B19 is the cause, code the infection separately (B34.3). In patients with pre-existing hemolytic anemia (sickle-cell disease, spherocytosis), a transient aplastic crisis can cause life-threatening anemia requiring emergency transfusion -

code both the underlying hemolytic anemia and the transient aplasia. Do not assign this code for the physiologic reticulocytopenia that occurs transiently after blood loss.

Common Mistakes

HCC Buddy guidance

D60.0 (Chronic acquired pure red cell aplasia) is for persistent conditions lasting beyond the expected transient period.

D61.01 (Constitutional pure red blood cell aplasia) is congenital Diamond-Blackfan anemia.

D60.9 (Acquired pure red cell aplasia, unspecified) does not specify whether the condition is transient or chronic.

D64.9 (Anemia, unspecified) is far less specific and should not be used when pure red cell aplasia is documented.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Is D60.1 an HCC code?

Yes. D60.1 maps to Severe Hematological Disorders under the V24 model but is not retained in V28.

HCC Category Mapping

V24HCC 46, Severe Hematological Disorders

0.666

ESRDHCC 46, Severe Hematological Disorders

0.000

RxHCCHCC 96, Hemolytic and Aplastic Anemias

0.000

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work D60.1 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for D60.1

For D60.1to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed D60.1 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

D60.1 is the ICD-10-CM diagnosis code for transient acquired pure red cell aplasia. A temporary condition where the bone marrow temporarily stops producing red blood cells, usually resolving on its own within weeks. D60.1 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering aplastic and other anemias and other bone marrow failure syndromes (d60-d64).

Under the older CMS-HCC V24 model, D60.1 maps to Severe Hematological Disorders (HCC 46) with a community, non-dual, aged base RAF weight of 0.666. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Verify documentation confirms the temporary nature and expected resolution of the condition. Because D60.1 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D60.1 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Verify documentation confirms the temporary nature and expected resolution of the condition
•If the condition persists beyond the expected timeframe, consider recoding to D60.0 or D60.9

Clinical Significance

Transient acquired pure red cell aplasia is a temporary cessation of red blood cell production by the bone marrow that typically resolves spontaneously within weeks. The most common cause is parvovirus B19 infection, which directly infects and destroys erythroid precursor cells, producing a transient aplastic crisis especially dangerous in patients with pre-existing hemolytic anemias who depend on compensatory increased red cell production. Other causes include certain medications and acute viral infections that temporarily suppress erythropoiesis.

Documentation Requirements

✓Document the temporary nature of the red cell aplasia with expected or actual resolution timeline.
✓Record parvovirus B19 serologies (immunoglobulin M for acute infection) or polymerase chain reaction when infection-associated.
✓Include hemoglobin values, reticulocyte count showing near-zero production, and normal white blood cell and platelet counts.
✓Document any causative agent or triggering event.
✓Record transfusion support provided during the aplastic episode and evidence of recovery.

Commonly Confused Codes

•D60.0 (Chronic acquired pure red cell aplasia) is for persistent conditions lasting beyond the expected transient period.
•D61.01 (Constitutional pure red blood cell aplasia) is congenital Diamond-Blackfan anemia.
•D60.9 (Acquired pure red cell aplasia, unspecified) does not specify whether the condition is transient or chronic.
•D64.9 (Anemia, unspecified) is far less specific and should not be used when pure red cell aplasia is documented.