Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero
Under the CMS-HCC V28 risk adjustment model (PY2026 Medicare Advantage), HCC 107 carries a community non-dual aged RAF of 0.457, and 14 payable ICD-10-CM diagnosis codes map to it.
Medically reviewed by Jess P., CPC · Reviewed: May 30, 2026
RAF factors
The community factor varies by Medicaid and originally-disabled status; the institutional factor applies to long-term-institutional members. These are the CMS-HCC V28 PY2026 relative factors.
Combine this factor with demographics and other HCCs in the RAF score calculator to model the full CMS-HCC V28 RAF for a member.
V28 hierarchy
Supersedes: HCC 108 (this category is counted instead of these when they co-occur).
ICD-10-CM codes that map to HCC 107 (14)
Payable diagnosis codes that map to this category under CMS-HCC V28 PY2026. Open any code for its full description, HCC mapping, and coding guidance.
- D57.00Hb-SS disease with crisis, unspecified
- D57.01Hb-SS disease with acute chest syndrome
- D57.02Hb-SS disease with splenic sequestration
- D57.03Hb-SS disease with cerebral vascular involvement
- D57.04Hb-SS disease with dactylitis
- D57.09Hb-SS disease with crisis with other specified complication
- D57.1Sickle-cell disease without crisis
- D57.42Sickle-cell thalassemia beta zero without crisis
- D57.431Sickle-cell thalassemia beta zero with acute chest syndrome
- D57.432Sickle-cell thalassemia beta zero with splenic sequestration
- D57.433Sickle-cell thalassemia beta zero with cerebral vascular involvement
- D57.434Sickle-cell thalassemia beta zero with dactylitis
- D57.438Sickle-cell thalassemia beta zero with crisis with other specified complication
- D57.439Sickle-cell thalassemia beta zero with crisis, unspecified
Coder workflow notes
Get the V28 RAF + MEAT cheat sheet
A printable one-pager for HCC 107: which member codes risk-adjust, the RAF weight, and the MEAT your notes need to make it stick. Free, no card.
Free PDF. No card. Unsubscribe anytime.
Frequently asked questions
What is CMS-HCC V28 category 107?
HCC 107 is "Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero", a payment Hierarchical Condition Category in the CMS-HCC V28 risk adjustment model (100% phase-in for payment year 2026). 14 payable ICD-10-CM codes map to it.
What is the RAF weight for HCC 107?
The community non-dual aged relative factor for CMS-HCC V28 category 107 is 0.457. The exact factor varies by enrollment segment (community Medicaid and originally-disabled status, and institutional); the full segment table is published in the CMS V28 Rate Announcement.
How many ICD-10-CM codes map to HCC 107?
14 payable ICD-10-CM diagnosis codes map to CMS-HCC V28 category 107 (Sickle Cell Anemia (Hb-SS) and Thalassemia Beta Zero) for payment year 2026.
Related references
Sources
CMS published ICD-10-CM mapping file plus CMS-HCC v28 PY2026 model software. CMS-HCC V28 model published at CMS.gov Risk Adjustors; ICD-10-CM member codes from the CMS ICD-10-CM code set.
Verified current to CMS-HCC V28, payment year 2026 — last reviewed May 30, 2026.