D72.0
BillableGenetic anomalies of leukocytes
HCC Category Mapping
V28HCC 115 — Disorders of Immunity, Neutropenia
0.369V24HCC 47 — Disorders of Immunity
0.472ESRDHCC 47 — Disorders of Immunity
0.000What This Code Means
A group of inherited disorders affecting the structure or development of white blood cells from birth.
Coding Tips
- •This code represents congenital/genetic conditions; verify family history and genetic testing results in the medical record.
- •Do not use this code for acquired white blood cell abnormalities; those require different coding.
Clinical Significance
Genetic anomalies of leukocytes encompass inherited conditions affecting white blood cell morphology or function, including Pelger-Huet anomaly (hypolobulated neutrophils), Alder-Reilly anomaly (abnormal granulation), Chediak-Higashi syndrome (giant granules with immunodeficiency), and other rare hereditary leukocyte disorders. Clinical significance varies from benign morphological variants to severe immunodeficiency syndromes.
Documentation Requirements
- ✓Document the specific leukocyte anomaly identified, peripheral blood smear or flow cytometry findings, genetic testing results if available, and clinical manifestations (recurrent infections, albinism in Chediak-Higashi).
- ✓Record family history consistent with the specific inheritance pattern and any associated features.
Excludes 1 — Do NOT code together
- Chédiak (-Steinbrinck)-Higashi syndrome (E70.330)
Commonly Confused Codes
D71 (Functional disorders of polymorphonuclear neutrophils) — acquired or functional defects rather than genetic structural anomaliesD70.0 (Congenital agranulocytosis) — quantitative deficiency rather than qualitative anomalyD80-D84 (Immunodeficiency codes) — may be needed additionally when the leukocyte anomaly causes immunodeficiency.
Code Hierarchy
└D72Other disorders of white blood cells└D72.0Genetic anomalies of leukocytes
└D72.0Genetic anomalies of leukocytes