D59.30

Billable

Hemolytic-uremic syndrome, unspecified

HCC Category Mapping

V28HCC 109 — Hemolytic and Aplastic Anemias

0.291

V24HCC 46 — Severe Hematological Disorders

0.666

ESRDHCC 46 — Severe Hematological Disorders

0.000

RxHCCHCC 96 — Hemolytic and Aplastic Anemias

0.000

What This Code Means

A serious condition characterized by the destruction of red blood cells and kidney failure, with the cause not specified.

Coding Tips

•This is an unspecified code; attempt to determine if the HUS is infection-associated (D59.31), hereditary (D59.32), or other (D59.39)
•Document severity and any complications such as acute kidney injury or neurological involvement

Clinical Significance

Hemolytic-uremic syndrome, unspecified is a life-threatening thrombotic microangiopathy characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and acute kidney injury. The unspecified designation indicates the documentation does not clarify whether the condition is infection-associated (typical), hereditary (atypical complement-mediated), or due to other causes. Prompt diagnosis and treatment are critical because delays significantly worsen renal outcomes and mortality risk.

Documentation Requirements

✓Document the triad of microangiopathic hemolytic anemia (schistocytes on blood smear), thrombocytopenia, and acute kidney injury with supporting laboratory values.
✓Record creatinine, blood urea nitrogen, platelet count, hemoglobin, lactate dehydrogenase, haptoglobin, and peripheral smear findings.
✓Query the provider to determine the specific type (infection-associated, hereditary, or other) for more accurate coding.
✓Document any dialysis requirement, plasma exchange therapy, or complement inhibitor use.

Commonly Confused Codes

D59.31 (Infection-associated hemolytic-uremic syndrome) is the most common type, usually from Shiga toxin-producing Escherichia coli.D59.32 (Hereditary hemolytic-uremic syndrome) involves complement pathway defects.D59.39 (Other hemolytic-uremic syndrome) covers drug-induced or other causes.M31.10 (Thrombotic thrombocytopenic purpura, unspecified) shares similar features but typically has more prominent neurological involvement and ADAMTS13 deficiency.

Code Hierarchy

└D59Acquired hemolytic anemia └D59.3Hemolytic-uremic syndrome └D59.30Hemolytic-uremic syndrome, unspecified

└D59.30Hemolytic-uremic syndrome, unspecified