D82.1 ICD-10-CM Code: Di George's syndrome
D82.1 maps to CMS-HCC V28 115 (RAF 0.565). Documentation must support MEAT. MEAT criteria · RAF calculator · free HCC coding tools
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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Certain disorders involving the immune mechanism (D80-D89)
D82.1
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceDi George's syndrome
A rare genetic disorder where the thymus gland (which produces immune cells) and parathyroid glands fail to develop properly, leading to immune deficiency and low calcium levels.
Buddy Insight
DiGeorge syndrome, also known as 22q11.
CMS-HCC V28
MappedHCC 115
RAF 0.565
CMS-HCC V24
MappedHCC 47
RAF 0.665
ACA/HHS
MappedHCC 73
Varies by metal level
ESRD/PACE
MappedHCC 47
RAF 0.078
RXHCC
MappedHCC 99
RAF 0.943
Code Book Path
Inclusion Terms
Official- Pharyngeal pouch syndrome
- Thymic alymphoplasia
- Thymic aplasia or hypoplasia with immunodeficiency
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for D82.1 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for D82.1 in this effective period.
Excludes 1
Official- ataxia telangiectasia [Louis-Bar] (G11.3)
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for D82.1 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for D82.1 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for D82.1 in this effective period.
Buddy Documentation Tip
MEAT Support
Audit Caution
Common Mistakes
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is D82.1 an HCC code?
Yes. D82.1 (Di George's syndrome) maps to Specified Immunodeficiencies and White Blood Cell Disorders under the CMS-HCC V28 risk adjustment model (and Disorders of Immunity under V24), with a community non-dual aged RAF of 0.565. It is billable for payment year 2026.
Coder answer: D82.1 is billable and maps to V28 HCC 115, Specified Immunodeficiencies and White Blood Cell Disorders. Open it in the Code Book for the tabular path, RAF, and MEAT checklist.
- Code
- D82.1
- Description
- Di George's syndrome
- HCC (V28)
- HCC 115 — Specified Immunodeficiencies and White Blood Cell Disorders
- RAF
- 0.565
- Billable
- Yes
- Payment year
- 2026
HCC Category Mapping
Each model's RAF is its CMS base weight for that model's standard population, so weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.
Work D82.1 in the Code Book — tabular path, V28 RAF, and MEAT checklist →
MEAT Criteria for D82.1
For D82.1 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.
- MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
- EEvaluate: test results, medication response, or physical findings reviewed by the provider
- AAssess: explicit mention in the assessment or plan with acknowledgment of status
- TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis
Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed D82.1 during that encounter, not just copy-forwarded from a problem list.
Coder workflow notes
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What This Code Means
D82.1 is the ICD-10-CM diagnosis code for di george's syndrome. A rare genetic disorder where the thymus gland (which produces immune cells) and parathyroid glands fail to develop properly, leading to immune deficiency and low calcium levels. D82.1 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).
Under the CMS-HCC V28 risk adjustment model, D82.1 maps to Specified Immunodeficiencies and White Blood Cell Disorders (HCC 115) with a community, non-dual, aged base RAF weight of 0.565. Under the older CMS-HCC V24 model, D82.1 maps to Disorders of Immunity (HCC 47) with a community, non-dual, aged base RAF weight of 0.665. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.
This syndrome involves multiple organ systems; document cardiac defects, cleft palate, and hypocalcemia separately if present. Because D82.1 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D82.1 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •This syndrome involves multiple organ systems; document cardiac defects, cleft palate, and hypocalcemia separately if present
- •Also known as 22q11 deletion syndrome; document associated conditions comprehensively for complete clinical documentation
Clinical Significance
DiGeorge syndrome, also known as 22q11.2 deletion syndrome, is a congenital immunodeficiency resulting from abnormal development of the third and fourth pharyngeal pouches, causing thymic hypoplasia or aplasia, parathyroid hypoplasia with hypocalcemia, conotruncal cardiac defects, and characteristic facial features. The immune deficiency primarily affects T-cell development due to absent or small thymus.
Documentation Requirements
- ✓Documentation must include genetic testing confirming 22q11.2 deletion (fluorescence in situ hybridization or chromosomal microarray), T-cell enumeration, cardiac evaluation results, calcium and parathyroid hormone levels, facial dysmorphology description, and developmental assessment.
- ✓Document the severity of immunodeficiency (complete vs.
- ✓partial DiGeorge) and all affected organ systems comprehensively.
Commonly Confused Codes
- •D81.4 (Nezelof syndrome with isolated T-cell deficiency without cardiac or parathyroid features), D81.2 (severe combined immunodeficiency with low or normal B-cells), D82.2 (immunodeficiency with short-limbed stature, a different syndromic immunodeficiency), Q93.81 (velocardiofacial syndrome which overlaps with 22q11 deletion but emphasizes different features).