D89.810

HCC Category Mapping

What This Code Means

A serious complication occurring shortly after a bone marrow or stem cell transplant where the donor's immune cells attack the recipient's body tissues.

Coding Tips

• •Document the timeline (typically within 100 days of transplant) and affected organs
• •Use with a code for the transplant procedure and specify affected body systems

Clinical Significance

Acute graft-versus-host disease is a potentially life-threatening immune complication occurring typically within the first 100 days after allogeneic hematopoietic stem cell transplantation, where donor immune cells attack the recipient's tissues. Primary target organs are skin (dermatitis), liver (elevated bilirubin), and gastrointestinal tract (diarrhea, abdominal pain). Severity grading (I-IV) guides treatment intensity, with Grade III-IV carrying significant mortality risk.

Documentation Requirements

• ✓Documentation must specify acute graft-versus-host disease with the organ systems involved (skin, liver, gastrointestinal), severity grading, and the temporal relationship to the transplant.
• ✓The type of transplant (allogeneic hematopoietic stem cell), conditioning regimen, and donor relationship should be recorded.
• ✓Current treatment including immunosuppressive therapy (corticosteroids, calcineurin inhibitors) and response to treatment must be documented.

Commonly Confused Codes