D89.81 ICD-10-CM Code: Graft-versus-host disease
D89.81 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · free HCC coding tools
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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Certain disorders involving the immune mechanism (D80-D89)
D89.81
Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidanceGraft-versus-host disease
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for D89.81. Check the code and parent instructions in the Code Book.
Excludes 2
Official- autoimmune disease (systemic) NOS (M35.9)Inherited from D50-D89, D89
- certain conditions originating in the perinatal period (P00-P96)Inherited from D50-D89, D89
- complications of pregnancy, childbirth and the puerperium (O00-O9A)Inherited from D50-D89, D89
- congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)Inherited from D50-D89, D89
- endocrine, nutritional and metabolic diseases (E00-E88)Inherited from D50-D89, D89
- human immunodeficiency virus [HIV] disease (B20)Inherited from D50-D89, D89
- injury, poisoning and certain other consequences of external causes (S00-T88)Inherited from D50-D89, D89
- neoplasms (C00-D49)Inherited from D50-D89, D89
- symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)Inherited from D50-D89, D89
- transplant failure and rejection (T86.-)Inherited from D50-D89, D89
Related Codes
Includes
Official- defects in the complement systemInherited from D80-D89
- immunodeficiency disorders, except human immunodeficiency virus [HIV] diseaseInherited from D80-D89
- sarcoidosisInherited from D80-D89
Excludes 1
Official- autoimmune disease (systemic) NOS (M35.9)Inherited from D80-D89, D89
- functional disorders of polymorphonuclear neutrophils (D71-)Inherited from D80-D89, D89
- human immunodeficiency virus [HIV] disease (B20)Inherited from D80-D89, D89
- hyperglobulinemia NOS (R77.1)Inherited from D80-D89, D89
- monoclonal gammopathy (of undetermined significance) (D47.2)Inherited from D80-D89, D89
Code First
Official- underlying cause, such as:
- complications of transplanted organs and tissue (T86.-)
- complications of blood transfusion (T80.89)
Use Additional
Official- code to identify associated manifestations, such as:
- desquamative dermatitis (L30.8)
- diarrhea (R19.7)
- elevated bilirubin (R17)
- hair loss (L65.9)
Code Also
OfficialNo Code Also instructions are included in this display for D89.81. Check the code and parent instructions in the Code Book.
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
- Code
- D89.81
- Description
- Graft-versus-host disease
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- No
- Payment year
- 2026
Coder workflow notes
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What This Code Means
D89.81 is the ICD-10-CM diagnosis code for graft-versus-host disease. D89.81 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).
Header codes like D89.81 cannot be reported on claims directly; they organize child codes that share clinical context. Coders should select the billable child code that matches the documented presentation and then verify its current source-backed HCC mapping. Do not infer a child code or risk adjustment value from the header alone.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for D89.81 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.