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D89 ICD-10-CM Code: Other disorders involving the immune mechanism, not elsewhere classified

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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Certain disorders involving the immune mechanism (D80-D89)

D89

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Other disorders involving the immune mechanism, not elsewhere classified

Other disorders involving the immune mechanism, not elsewhere classified

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
D8Certain disorders involving the immune mechanism (D80-D89)
D89Other disorders involving the immune mechanism, not elsewhere classified

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for D89 in this effective period.

Excludes 2

Official
  • transplant failure and rejection (T86.-)

Related Child Codes

Official
D89.0Polyclonal hypergammaglobulinemia
D89.1Cryoglobulinemia
D89.2Hypergammaglobulinemia, unspecified
D89.3Immune reconstitution syndrome
D89.4Mast cell activation syndrome and related disorders

Includes

Official

ICD-10-CM does not list Includes notes for D89 in this effective period.

Excludes 1

Official
  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for D89 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for D89 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for D89 in this effective period.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

What This Code Means

D89 is the ICD-10-CM diagnosis code for other disorders involving the immune mechanism, not elsewhere classified. D89 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering certain disorders involving the immune mechanism (d80-d89).

Header codes like D89 cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at D89's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D89 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Excludes 1, Do NOT code together

  • hyperglobulinemia NOS (R77.1)
  • monoclonal gammopathy (of undetermined significance) (D47.2)

Excludes 2, Not included here, may code separately

  • transplant failure and rejection (T86.-)

Child Codes

Code Hierarchy

D89Other disorders involving the immune mechanism, not elsewhere classified
D89Other disorders involving the immune mechanism, not elsewhere classified

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