D83.0

HCC Category Mapping

What This Code Means

A common immune disorder where the body doesn't produce enough antibodies or the B cells that make them don't function properly.

Coding Tips

• •Document specific B-cell count abnormalities and functional deficits from immunological testing
• •Distinguish from D83.1 and D83.2 by confirming the primary problem is B-cell related, not T-cell or autoimmune

Clinical Significance

Common variable immunodeficiency with predominant abnormalities of B-cell numbers and function is the most common symptomatic primary immunodeficiency in adults, characterized by significantly reduced B-cell numbers or function leading to hypogammaglobulinemia. Patients present with recurrent sinopulmonary infections, gastrointestinal disease, granulomatous inflammation, and increased risk of autoimmune cytopenias and lymphoid malignancy.

Documentation Requirements

• ✓Documentation must include quantitative immunoglobulin levels (Immunoglobulin G, Immunoglobulin A, and often Immunoglobulin M significantly reduced), B-cell enumeration by flow cytometry, poor response to vaccination challenge testing, clinical manifestations including infection history, and treatment with immunoglobulin replacement therapy.
• ✓Specify that B-cell abnormalities are the predominant finding to justify D83.0 over D83.1 or D83.2.

Commonly Confused Codes