D61.82
BillableMyelophthisis
HCC Category Mapping
What This Code Means
A condition where the bone marrow is replaced or infiltrated by abnormal tissue, preventing it from producing normal blood cells.
Coding Tips
- •Link to the underlying condition causing bone marrow infiltration (malignancy, fibrosis, etc.)
- •Document the type of infiltrating process when documented in the medical record
Clinical Significance
Myelophthisis describes bone marrow failure caused by replacement of normal hematopoietic tissue by abnormal cells or fibrous tissue, disrupting normal blood cell production. The most common cause is metastatic cancer infiltrating the bone marrow (especially breast, prostate, lung, and neuroblastoma), but other causes include myelofibrosis, storage diseases (Gaucher disease), and granulomatous infections. A characteristic leukoerythroblastic blood picture with immature white blood cells and nucleated red blood cells in the peripheral blood results from the displaced hematopoietic cells being prematurely released.
Documentation Requirements
- ✓Document the underlying condition causing bone marrow infiltration (specific malignancy, fibrosis, storage disease, or granulomatous process).
- ✓Record bone marrow biopsy findings showing replacement of normal hematopoietic tissue by abnormal cells or fibrosis.
- ✓Include complete blood count values and peripheral blood smear findings (leukoerythroblastic picture, teardrop cells).
- ✓Document the primary condition as the underlying cause and code it separately.
- ✓Note any treatment directed at the infiltrating process.