FY2027 ICD-10-CM reference
D80.3: Selective deficiency of immunoglobulin G [IgG] subclasses
By the HCC Buddy Coding Team
The official ICD-10-CM descriptor is Selective deficiency of immunoglobulin G [IgG] subclasses. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Billable code. Verified against the official FY2027 order file.
FY2027 Tabular instructions
Instructions below include applicable chapter, section and parent-code notes. Each note identifies where it appears in the official source.
Excludes2
autoimmune disease (systemic) NOS (M35.9)
Source: D50-D89 (chapter, inherited).
Excludes2
certain conditions originating in the perinatal period (P00-P96)
Source: D50-D89 (chapter, inherited).
Excludes2
complications of pregnancy, childbirth and the puerperium (O00-O9A)
Source: D50-D89 (chapter, inherited).
Excludes2
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
Source: D50-D89 (chapter, inherited).
Excludes2
endocrine, nutritional and metabolic diseases (E00-E88)
Source: D50-D89 (chapter, inherited).
Excludes2
human immunodeficiency virus [HIV] disease (B20)
Source: D50-D89 (chapter, inherited).
Excludes2
injury, poisoning and certain other consequences of external causes (S00-T88)
Source: D50-D89 (chapter, inherited).
Excludes2
neoplasms (C00-D49)
Source: D50-D89 (chapter, inherited).
Excludes2
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: D50-D89 (chapter, inherited).
Includes
defects in the complement system
Source: D80-D89 (section, inherited).
Includes
immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
Source: D80-D89 (section, inherited).
Includes
sarcoidosis
Source: D80-D89 (section, inherited).
Excludes1
autoimmune disease (systemic) NOS (M35.9)
Source: D80-D89 (section, inherited).
Excludes1
functional disorders of polymorphonuclear neutrophils (D71-)
Source: D80-D89 (section, inherited).
Excludes2
human immunodeficiency virus [HIV] disease (B20)
Source: D80-D89 (section, inherited).
Compare the FY2027 additions, removals and billable-status changes
What does D80.3 mean in FY2027?
The official ICD-10-CM descriptor is Selective deficiency of immunoglobulin G [IgG] subclasses. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Is D80.3 billable in FY2027?
The FY2027 order file marks D80.3 as billable. Check the complete Tabular instructions and documentation before assigning it.
Does D80.3 map to an HCC?
In the CMS 2027 Initial ICD-10-CM Mappings (payment year 2027, 2026 dates of service), D80.3 maps to CMS-HCC V28 HCC 115 (Specified Immunodeficiencies and White Blood Cell Disorders). For 2027 dates of service, CMS has not yet published the payment year 2028 mappings. ESRD, RxHCC, PACE and HHS-HCC mappings are still pending verification for FY2027.
Source: CMS FY2027 ICD-10-CM order file. Read the FY2027 Official Guidelines.
Review the FY2026 April edition