FY2027 ICD-10-CM reference
D80: Immunodeficiency with predominantly antibody defects
By the HCC Buddy Coding Team
The official ICD-10-CM descriptor is Immunodeficiency with predominantly antibody defects. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Nonbillable heading. Verified against the official FY2027 order file.
More specific FY2027 codes
- D80.0: Hereditary hypogammaglobulinemiaBillable code
- D80.1: Nonfamilial hypogammaglobulinemiaBillable code
- D80.2: Selective deficiency of immunoglobulin A [IgA]Billable code
- D80.3: Selective deficiency of immunoglobulin G [IgG] subclassesBillable code
- D80.4: Selective deficiency of immunoglobulin M [IgM]Billable code
- D80.5: Immunodeficiency with increased immunoglobulin M [IgM]Billable code
- D80.6: Antibody deficiency with near-normal immunoglobulins or with hyperimmunoglobulinemiaBillable code
- D80.7: Transient hypogammaglobulinemia of infancyBillable code
- D80.8: Other immunodeficiencies with predominantly antibody defectsBillable code
- D80.9: Immunodeficiency with predominantly antibody defects, unspecifiedBillable code
FY2027 Tabular instructions
Instructions below include applicable chapter, section and parent-code notes. Each note identifies where it appears in the official source.
Excludes2
autoimmune disease (systemic) NOS (M35.9)
Source: D50-D89 (chapter, inherited).
Excludes2
certain conditions originating in the perinatal period (P00-P96)
Source: D50-D89 (chapter, inherited).
Excludes2
complications of pregnancy, childbirth and the puerperium (O00-O9A)
Source: D50-D89 (chapter, inherited).
Excludes2
congenital malformations, deformations and chromosomal abnormalities (Q00-Q99)
Source: D50-D89 (chapter, inherited).
Excludes2
endocrine, nutritional and metabolic diseases (E00-E88)
Source: D50-D89 (chapter, inherited).
Excludes2
human immunodeficiency virus [HIV] disease (B20)
Source: D50-D89 (chapter, inherited).
Excludes2
injury, poisoning and certain other consequences of external causes (S00-T88)
Source: D50-D89 (chapter, inherited).
Excludes2
neoplasms (C00-D49)
Source: D50-D89 (chapter, inherited).
Excludes2
symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R94)
Source: D50-D89 (chapter, inherited).
Includes
defects in the complement system
Source: D80-D89 (section, inherited).
Includes
immunodeficiency disorders, except human immunodeficiency virus [HIV] disease
Source: D80-D89 (section, inherited).
Includes
sarcoidosis
Source: D80-D89 (section, inherited).
Excludes1
autoimmune disease (systemic) NOS (M35.9)
Source: D80-D89 (section, inherited).
Excludes1
functional disorders of polymorphonuclear neutrophils (D71-)
Source: D80-D89 (section, inherited).
Excludes2
human immunodeficiency virus [HIV] disease (B20)
Source: D80-D89 (section, inherited).
Compare the FY2027 additions, removals and billable-status changes
What does D80 mean in FY2027?
The official ICD-10-CM descriptor is Immunodeficiency with predominantly antibody defects. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Is D80 billable in FY2027?
The FY2027 order file marks D80 as a nonbillable heading. Select a complete billable child code.
Does D80 map to an HCC?
Risk-model mapping is not applicable to this nonbillable heading. Check a complete billable child code.
Source: CMS FY2027 ICD-10-CM order file. Payment model: CMS CY 2027 Rate Announcement. Read the FY2027 Official Guidelines.
Review the FY2026 April edition