V28 HCC 50
Amyloidosis, Porphyria, and Other Specified Metabolic Disorders
Under the CMS-HCC V28 risk adjustment model (PY2026 Medicare Advantage), HCC 50 has a source-labeled community non-dual aged reference coefficient of 0.648, and 31 ICD-10-CM diagnosis codes appear in its official mapping.
RAF factors
The community factor varies by Medicaid and originally-disabled status; the institutional factor applies to long-term-institutional members. These are the CMS-HCC V28 PY2026 relative factors.
These are source-labeled code-level HCC coefficient references, not a full member score. Use the RAF Calculator with complete member context for CMS-HCC V28 PY2026. No score is shown unless every required source and calculation check passes.
ICD-10-CM codes that map to HCC 50 (31)
ICD-10-CM codes in the official mapping for this category under CMS-HCC V28 PY2026. Open any code for its full description and coding guidance.
- E72.530Primary hyperoxaluria, type 1
- E72.538Other specified primary hyperoxaluria
- E72.539Primary hyperoxaluria, unspecified
- E74.00Glycogen storage disease, unspecified
- E74.01von Gierke disease
- E74.03Cori disease
- E74.04McArdle disease
- E74.05Lysosome-associated membrane protein 2 [LAMP2] deficiency
- E74.09Other glycogen storage disease
- E79.1Lesch-Nyhan syndrome
- E80.0Hereditary erythropoietic porphyria
- E80.1Porphyria cutanea tarda
- E80.20Unspecified porphyria
- E80.21Acute intermittent (hepatic) porphyria
- E80.29Other porphyria
- E80.3Defects of catalase and peroxidase
- E83.00Disorder of copper metabolism, unspecified
- E83.01Wilson's disease
- E83.09Other disorders of copper metabolism
- E83.31Familial hypophosphatemia
- E85.0Non-neuropathic heredofamilial amyloidosis
- E85.1Neuropathic heredofamilial amyloidosis
- E85.2Heredofamilial amyloidosis, unspecified
- E85.3Secondary systemic amyloidosis
- E85.4Organ-limited amyloidosis
- E85.81Light chain (AL) amyloidosis
- E85.82Wild-type transthyretin-related (ATTR) amyloidosis
- E85.89Other amyloidosis
- E85.9Amyloidosis, unspecified
- E88.01Alpha-1-antitrypsin deficiency
- E88.89Other specified metabolic disorders
Coder workflow notes
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Frequently asked questions
What is CMS-HCC V28 category 50?
HCC 50 is "Amyloidosis, Porphyria, and Other Specified Metabolic Disorders", a Hierarchical Condition Category in the CMS-HCC V28 risk adjustment model (100% phase-in for payment year 2026). 31 ICD-10-CM codes appear in its official mapping.
What reference coefficient is published for HCC 50?
The source-labeled community non-dual aged reference coefficient for CMS-HCC V28 category 50 is 0.648. The exact coefficient varies by enrollment segment (community Medicaid and originally-disabled status, and institutional); the full segment table is published in the CMS V28 model files.
How many ICD-10-CM codes map to HCC 50?
31 ICD-10-CM diagnosis codes appear in the official mapping for CMS-HCC V28 category 50 (Amyloidosis, Porphyria, and Other Specified Metabolic Disorders) for payment year 2026.
Related references
Sources
CMS ICD-10-CM order-file billability plus the published mapping and CMS-HCC V28 PY2026 model software. CMS-HCC V28 model published at CMS.gov Risk Adjustors; ICD-10-CM member codes from the CMS ICD-10-CM code set.
Verified current to CMS-HCC V28, payment year 2026 — last reviewed May 30, 2026.