E85.4
BillableOrgan-limited amyloidosis
HCC Category Mapping
V28HCC 50 — Glycogen/Amino-Acid/Other Metabolic Disorders
0.289V24HCC 23 — Other Significant Endocrine and Metabolic Disorders
0.230ESRDHCC 23 — Other Significant Endocrine and Metabolic Disorders
0.000What This Code Means
Organ-limited amyloidosis is a localized form where abnormal protein deposits affect only one specific organ, such as the heart, kidneys, or skin, rather than multiple body systems.
Coding Tips
- •Specify which organ is affected in the documentation; this helps clarify the extent and prognosis of the disease
- •Ensure the amyloidosis is truly limited to one organ; if multiple organs are involved, use a different E85 code
Clinical Significance
Organ-limited (localized) amyloidosis involves amyloid deposition confined to a single organ, such as the bladder, skin, larynx, or tracheobronchial tree. Unlike systemic forms, it generally has a better prognosis and does not progress to multi-organ involvement, though it may cause significant local symptoms.
Documentation Requirements
- ✓Confirmed amyloidosis diagnosis by tissue biopsy of the affected organ
- ✓Documentation that amyloid deposits are LIMITED to a single organ
- ✓Specific organ involved identified in documentation
- ✓Exclusion of systemic amyloidosis (no evidence of multi-organ involvement)
- ✓Monitoring plan to ensure the condition remains localized
- ✓Treatment approach for the affected organ
Commonly Confused Codes
E85.3 — Secondary systemic amyloidosis: systemic form involving multiple organsE85.81 — Light chain (AL) amyloidosis: systemic primary amyloidosisE85.82 — Wild-type transthyretin-related (ATTR) amyloidosis: systemic formE85.89 — Other amyloidosis: use for specified systemic forms not elsewhere classified