E80.3
BillableDefects of catalase and peroxidase
HCC Category Mapping
V28HCC 50 — Glycogen/Amino-Acid/Other Metabolic Disorders
0.289V24HCC 23 — Other Significant Endocrine and Metabolic Disorders
0.230ESRDHCC 23 — Other Significant Endocrine and Metabolic Disorders
0.000RxHCCHCC 43 — Other Significant Endocrine and Metabolic Disorders
0.000What This Code Means
A rare genetic condition where the body lacks or has defective enzymes (catalase or peroxidase) that normally break down harmful hydrogen peroxide in cells.
Coding Tips
- •This is a rare metabolic disorder; ensure documentation clearly identifies the specific enzyme deficiency
- •May be associated with other systemic manifestations that should be coded separately
Clinical Significance
Defects of catalase and peroxidase includes acatalasia (catalase deficiency), also known as Takahara disease. While often asymptomatic, affected individuals may develop oral ulcerations and gangrene due to inability to decompose hydrogen peroxide. Myeloperoxidase deficiency, the most common inherited neutrophil disorder, is also captured here.
Documentation Requirements
- ✓Specific enzyme deficiency documented (catalase deficiency/acatalasia or peroxidase deficiency/myeloperoxidase deficiency)
- ✓Confirmatory enzyme activity testing or genetic testing
- ✓Clinical manifestations: oral ulcers and gangrene (acatalasia), recurrent infections (myeloperoxidase deficiency)
- ✓Functional impact on patient's health
- ✓Treatment and management plan
Commonly Confused Codes
D71 — Functional disorders of polymorphonuclear neutrophils: myeloperoxidase deficiency may be coded here as a neutrophil function disorderE80.29 — Other porphyria: peroxidase defects are not porphyrias despite being in the same sectionK12.1 — Other forms of stomatitis: oral ulcers in acatalasia need the metabolic code, not just the symptom codeE80.20 — Unspecified porphyria: do not confuse catalase/peroxidase defects with porphyrias
Code Hierarchy
└E80Disorders of porphyrin and bilirubin metabolism└E80.3Defects of catalase and peroxidase
└E80.3Defects of catalase and peroxidase