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E80 ICD-10-CM Code: Disorders of porphyrin and bilirubin metabolism

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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E80

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Disorders of porphyrin and bilirubin metabolism

Disorders of porphyrin and bilirubin metabolism

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
E8Metabolic disorders (E70-E88)
E80Disorders of porphyrin and bilirubin metabolism

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for E80 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E80 in this effective period.

Related Child Codes

Official
E80.0Hereditary erythropoietic porphyria
E80.1Porphyria cutanea tarda
E80.2Other and unspecified porphyria
E80.3Defects of catalase and peroxidase
E80.4Gilbert syndrome

Includes

Official
  • defects of catalase and peroxidase

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for E80 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E80 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E80 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E80 in this effective period.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

What This Code Means

E80 is the ICD-10-CM diagnosis code for disorders of porphyrin and bilirubin metabolism. E80 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

Header codes like E80 cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at E80's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E80 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Includes

  • defects of catalase and peroxidase

Child Codes

Code Hierarchy

E80Disorders of porphyrin and bilirubin metabolism
E80Disorders of porphyrin and bilirubin metabolism

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