E80.5 ICD-10-CM Code: Crigler-Najjar syndrome
HCC Buddy Code Card
Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.
FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)
E80.5
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceCrigler-Najjar syndrome
A rare inherited disorder where the liver cannot properly process bilirubin, leading to severe jaundice in newborns and potential brain damage if untreated.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialICD-10-CM does not list inclusion terms for E80.5 in this effective period.
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E80.5 in this effective period.
Related Child Codes
Includes
Official- defects of catalase and peroxidase
Excludes 1
OfficialICD-10-CM does not list Excludes 1 notes for E80.5 in this effective period.
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E80.5 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for E80.5 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for E80.5 in this effective period.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E80.5 an HCC code?
No. E80.5 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
- Code
- E80.5
- Description
- Crigler-Najjar syndrome
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
E80.5 is the ICD-10-CM diagnosis code for crigler-najjar syndrome. A rare inherited disorder where the liver cannot properly process bilirubin, leading to severe jaundice in newborns and potential brain damage if untreated. E80.5 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).
E80.5 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Specify Type I or Type II Crigler-Najjar syndrome when documented, as they have different severity levels.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E80.5 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Specify Type I or Type II Crigler-Najjar syndrome when documented, as they have different severity levels
- •Often requires phototherapy or exchange transfusion in neonates; coordinate coding with newborn complications