E22 ICD-10-CM Code: Hyperfunction of pituitary gland
E22 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · free HCC coding tools
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)
E22
Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidanceHyperfunction of pituitary gland
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for E22. Check the code and parent instructions in the Code Book.
Excludes 2
OfficialNo Excludes 2 notes are included in this display for E22. Check the code and parent instructions in the Code Book.
Related Codes
Includes
OfficialNo Includes notes are included in this display for E22. Check the code and parent instructions in the Code Book.
Excludes 1
Official- Cushing's syndrome (E24.-)
- Nelson's syndrome (E24.1)
- overproduction of ACTH not associated with Cushing's disease (E27.0)
- overproduction of pituitary ACTH (E24.0)
- overproduction of thyroid-stimulating hormone (E05.8-)
- transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89, E20-E35
- galactorrhea (N64.3)Inherited from E00-E89, E20-E35
- gynecomastia (N62)Inherited from E00-E89, E20-E35
Code First
OfficialNo Code First sequencing instructions are included in this display for E22. Check the code and parent instructions in the Code Book.
Use Additional
OfficialNo Use Additional Code instructions are included in this display for E22. Check the code and parent instructions in the Code Book.
Code Also
OfficialNo Code Also instructions are included in this display for E22. Check the code and parent instructions in the Code Book.
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
- Code
- E22
- Description
- Hyperfunction of pituitary gland
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- No
- Payment year
- 2026
Coder workflow notes
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What This Code Means
E22 is the ICD-10-CM diagnosis code for hyperfunction of pituitary gland. E22 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).
Header codes like E22 cannot be reported on claims directly; they organize child codes that share clinical context. Coders should select the billable child code that matches the documented presentation and then verify its current source-backed HCC mapping. Do not infer a child code or risk adjustment value from the header alone.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E22 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.