What is ICD-10 code E22.8?

E22.8 is the ICD-10-CM diagnosis code for Other hyperfunction of pituitary gland. Other specified conditions where the pituitary gland produces excessive hormones not covered by the more specific E22 codes. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E22.8 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E22.8 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E22.8 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E22.8 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

What is the V28 vs V24 difference for E22.8?

CMS phased in the V28 risk adjustment model over payment years 2024 (33%), 2025 (67%), and 2026 (100%), replacing V24. V28 consolidates HCC categories, removes some lower-acuity conditions, and recalibrates RAF weights across the entire model. E22.8 was a payment HCC under V24 (Other Significant Endocrine and Metabolic Disorders) but the V28 recalibration removed it from the risk adjustment model. Both models can still appear in legacy data and in payer-specific lookback periods.

What should coders know when reporting E22.8?

Use this code for documented pituitary hormone excess that doesn't fit E22.0, E22.1, or E22.2 Ensure documentation clearly describes which pituitary hormone is elevated to justify use of this code Because E22.8 maps to a payment HCC, the documentation must also satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's risk adjustment score.

2026 ICD-10-CM E22.8: Other hyperfunction

ICD-10-CM Code View

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Code lookupE22.8Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)

E22.8

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Other hyperfunction of pituitary gland

Other specified conditions where the pituitary gland produces excessive hormones not covered by the more specific E22 codes.

Buddy Insight

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.194

ACA/HHS

Mapped

HCC 30

HHS-HCC 30

Varies by metal level

ESRD/PACE

Mapped

HCC 23

Other Significant Endocrine a...

RAF 0.036

RXHCC

Mapped

HCC 43

Other Significant Endocrine a...

RAF 0.063

Code Book Path

Official

E22Hyperfunction of pituitary gland

E22.8Other hyperfunction of pituitary gland

Inclusion Terms

Official

Central precocious puberty

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E22.8 in this effective period.

Related Child Codes

Official

E22.0Acromegaly and pituitary gigantism

E22.1Hyperprolactinemia

E22.2Syndrome of inappropriate secretion of antidiuretic hormone

E22.9Hyperfunction of pituitary gland, unspecified

Includes

Official

ICD-10-CM does not list Includes notes for E22.8 in this effective period.

Excludes 1

Official

Cushing's syndrome (E24.-)
Nelson's syndrome (E24.1)
overproduction of ACTH not associated with Cushing's disease (E27.0)
overproduction of pituitary ACTH (E24.0)
overproduction of thyroid-stimulating hormone (E05.8-)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E22.8 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E22.8 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E22.8 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Document the specific pituitary hormone that is elevated, lab values confirming excess production, underlying etiology (adenoma, hyperplasia), clinical manifestations, and treatment approach.

MEAT Support

HCC Buddy guidance

Document the specific pituitary hormone that is elevated, lab values confirming excess production, underlying etiology (adenoma, hyperplasia), clinical manifestations, and treatment approach.

Audit Caution

HCC Buddy guidance

Ensure the specific hormone excess does not have a more precise code in E22.0-E22.2 before using this residual category.

Document clearly which hormone is elevated to justify this code selection over the unspecified E22.9.

Common Mistakes

HCC Buddy guidance

E22.0 (acromegaly/gigantism from growth hormone excess), E22.1 (hyperprolactinemia), E22.2 (syndrome of inappropriate antidiuretic hormone), E22.9 (unspecified pituitary hyperfunction).

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E22.8 an HCC code?

Yes. E22.8 maps to Other Significant Endocrine and Metabolic Disorders under the V24 model but is not retained in V28.

Code: E22.8
Description: Other hyperfunction of pituitary gland
HCC (V28): No CMS-HCC V28 mapping
RAF: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

V24HCC 23, Other Significant Endocrine and Metabolic Disorders

0.194

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders

0.036

RxHCCHCC 43, Other Significant Endocrine and Metabolic Disorders

0.063

Each model's RAF is its CMS base weight for that model's standard population, so weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

Work E22.8 in the Code Book — tabular path, V28 RAF, and MEAT checklist →

MEAT Criteria for E22.8

For E22.8 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E22.8 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

E22.8 is the ICD-10-CM diagnosis code for other hyperfunction of pituitary gland. Other specified conditions where the pituitary gland produces excessive hormones not covered by the more specific E22 codes. E22.8 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).

Under the older CMS-HCC V24 model, E22.8 maps to Other Significant Endocrine and Metabolic Disorders (HCC 23) with a community, non-dual, aged base RAF weight of 0.194. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Use this code for documented pituitary hormone excess that doesn't fit E22.0, E22.1, or E22.2. Because E22.8 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E22.8 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Use this code for documented pituitary hormone excess that doesn't fit E22.0, E22.1, or E22.2
•Ensure documentation clearly describes which pituitary hormone is elevated to justify use of this code

Clinical Significance

Other hyperfunction of the pituitary gland captures excess production of pituitary hormones not classified under acromegaly, hyperprolactinemia, or syndrome of inappropriate antidiuretic hormone secretion. This includes conditions like excessive thyroid-stimulating hormone or luteinizing hormone production from pituitary sources.

Documentation Requirements

✓Document the specific pituitary hormone that is elevated, lab values confirming excess production, underlying etiology (adenoma, hyperplasia), clinical manifestations, and treatment approach.

Commonly Confused Codes

•E22.0 (acromegaly/gigantism from growth hormone excess), E22.1 (hyperprolactinemia), E22.2 (syndrome of inappropriate antidiuretic hormone), E22.9 (unspecified pituitary hyperfunction).