E24.0

Billable

Pituitary-dependent Cushing's disease

HCC Category Mapping

V28HCC 51 — Other Significant Endocrine and Metabolic Disorders

0.233

V24HCC 23 — Other Significant Endocrine and Metabolic Disorders

0.230

ESRDHCC 23 — Other Significant Endocrine and Metabolic Disorders

0.000

RxHCCHCC 42 — Endocrine Disorders and Metabolic Conditions

0.000

What This Code Means

Cushing's disease caused by a tumor in the pituitary gland that produces excess ACTH hormone, leading to overproduction of cortisol.

Coding Tips

•This code specifically indicates the pituitary is the source; do not use if the ACTH source is ectopic or adrenal
•Often requires additional coding for any associated complications or treatment

Clinical Significance

Pituitary-dependent Cushing disease is the most common endogenous cause of Cushing syndrome, caused by an adrenocorticotropic hormone-secreting pituitary adenoma leading to bilateral adrenal hyperplasia and cortisol excess. It causes severe metabolic complications including central obesity, diabetes, hypertension, osteoporosis, immunosuppression, and psychiatric disorders.

Documentation Requirements

✓Document the pituitary adenoma confirmation (MRI findings, petrosal sinus sampling), 24-hour urinary free cortisol and midnight salivary cortisol levels, adrenocorticotropic hormone levels, dexamethasone suppression test results, complications present, and treatment plan (transsphenoidal surgery, radiation, medical therapy).

Commonly Confused Codes

E24.2 (drug-induced Cushing syndrome from exogenous corticosteroids), E24.3 (ectopic adrenocorticotropic hormone syndrome from non-pituitary tumors), E24.9 (Cushing syndrome unspecified), E22.0 (acromegaly, a different pituitary adenoma type).

Code Hierarchy

└E24Cushing's syndrome └E24.0Pituitary-dependent Cushing's disease

└E24.0Pituitary-dependent Cushing's disease