Skip to content

R64

Billable

Cachexia

Last updated: FY2026 ICD-10-CM (Oct 1, 2025 – Sep 30, 2026) | CMS-HCC V28 (100% phase-in, PY2026)

Is R64 an HCC code?

Yes. R64 maps to Protein-Calorie Malnutrition under the V24 model but is not retained in V28.

HCC Category Mapping

V24HCC 21Protein-Calorie Malnutrition
0.455
ESRDHCC 21Protein-Calorie Malnutrition
0.068

RAF weights shown are the community, non-dual, aged base weights from the CMS risk adjustment model file. Actual per-patient RAF contribution depends on member segment, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains in use during the transition and for historical data.

MEAT Criteria for R64

For R64to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically — it has to be re-documented and supported each calendar year.

  • MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
  • EEvaluate: test results, medication response, or physical findings reviewed by the provider
  • AAssess: explicit mention in the assessment or plan with acknowledgment of status
  • TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed R64 during that encounter — not just copy-forwarded from a problem list.

What This Code Means

R64 is the ICD-10-CM diagnosis code for cachexia. Severe wasting and loss of muscle mass and body weight, often seen in advanced cancer, chronic illness, or severe malnutrition. R64 sits in the ICD-10-CM chapter for symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (r00-r99), within the section covering general symptoms and signs (r50-r69).

Under the older CMS-HCC V24 model, R64 maps to Protein-Calorie Malnutrition (HCC 21) with a community, non-dual, aged base RAF weight of 0.455. V28 is the CMS-HCC risk adjustment model that reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition.

Cachexia is a sign of serious underlying disease; always investigate and code the primary condition. Because R64 maps to a payment HCC, the provider's documentation must satisfy MEAT criteria (Monitor, Evaluate, Assess, or Treat) for the encounter to count toward the patient's Medicare Advantage risk adjustment score. When documentation is ambiguous, coders should issue a provider query rather than assume the highest-specificity variant.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for R64 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • Cachexia is a sign of serious underlying disease; always investigate and code the primary condition
  • Document the degree of weight loss and functional decline to support medical necessity

Clinical Significance

Cachexia represents severe protein-energy malnutrition with significant muscle wasting that dramatically increases morbidity and mortality risk. This condition indicates advanced disease state requiring intensive nutritional intervention and impacts multiple body systems and functional status.

Documentation Requirements

  • Documentation of severe weight loss (>5% in 6 months)
  • Evidence of muscle wasting and weakness
  • Underlying disease process causing cachexia
  • Nutritional assessment results
  • Functional status decline
  • Laboratory values showing protein deficiency
  • Interventions attempted for nutritional support
  • Prognosis and goals of care discussions

Excludes 1 — Do NOT code together

  • abnormal weight loss (R63.4)
  • cachexia due to underlying condition (E88.A)
  • nutritional marasmus (E41)

Commonly Confused Codes

  • E43 — Unspecified severe protein-energy malnutrition (primary malnutrition)
  • R63.4 — Abnormal weight loss (less severe, no muscle wasting)
  • Z87.39 — Personal history of other endocrine, nutritional disorder
  • E46 — Unspecified protein-energy malnutrition (less severe)

Code Hierarchy

R64Cachexia
R64Cachexia

More on R64

Related condition guides

Open R64 in the Interactive Encoder

See full code details, AI coding tips, HCC mappings, and related codes in our interactive encoder. Start your 14-day Pro trial — no credit card required.