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E25 ICD-10-CM Code: Adrenogenital disorders

ICD-10-CM Code View

HCC Buddy Code Card

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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)

E25

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Adrenogenital disorders

Adrenogenital disorders

CMS-HCC V28

N/A

Not mapped

CMS-HCC V24

N/A

Not mapped

ACA/HHS

N/A

Not mapped

ESRD/PACE

N/A

Not mapped

RXHCC

N/A

Not mapped

Code Book Path

Official
E2Disorders of other endocrine glands (E20-E35)
E25Adrenogenital disorders

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for E25 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E25 in this effective period.

Related Child Codes

Official
E25.0Congenital adrenogenital disorders associated with enzyme deficiency
E25.8Other adrenogenital disorders
E25.9Adrenogenital disorder, unspecified

Includes

Official
  • adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
  • Female adrenal pseudohermaphroditism
  • Female heterosexual precocious pseudopuberty
  • Male isosexual precocious pseudopuberty
  • Male macrogenitosomia praecox

Excludes 1

Official
  • indeterminate sex and pseudohermaphroditism (Q56)
  • chromosomal abnormalities (Q90-Q99)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E25 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E25 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E25 in this effective period.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

Coder workflow notes

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What This Code Means

E25 is the ICD-10-CM diagnosis code for adrenogenital disorders. E25 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).

Header codes like E25 cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at E25's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E25 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Includes

  • adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesis
  • Female adrenal pseudohermaphroditism
  • Female heterosexual precocious pseudopuberty
  • Male isosexual precocious pseudopuberty
  • Male macrogenitosomia praecox
  • Male sexual precocity with adrenal hyperplasia
  • Male virilization (female)

Excludes 1, Do NOT code together

  • indeterminate sex and pseudohermaphroditism (Q56)
  • chromosomal abnormalities (Q90-Q99)

Child Codes

Code Hierarchy

E25Adrenogenital disorders
E25Adrenogenital disorders

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