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E25.8 ICD-10-CM Code: Other adrenogenital disorders

E25.8 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC coding software

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Code lookupE25.8

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)

E25.8

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Other adrenogenital disorders

Other types of adrenogenital disorders not classified elsewhere, including acquired forms or atypical presentations of adrenal hormone imbalances.

Buddy the Bee presenting code insight

Buddy Insight

Other adrenogenital disorders captures acquired forms of adrenal androgen excess or other adrenogenital conditions not caused by congenital enzyme deficiency.

OverviewRisk ModelsCode BookDocumentationAuditNotesEdition comparison

CMS-HCC V28

N/A

—

Not mapped

CMS-HCC V24

Historical

Historical

Not used for CY2026 payment

ACA/HHS

HCC 030

Code-level coefficient reference

ESRD/PACE

HCC 23

Code-level coefficient reference

RXHCC

HCC 43

Code-level coefficient reference

Code Book Path

Official
E25Adrenogenital disordersE25.8Other adrenogenital disorders

Inclusion Terms

Official
  • Idiopathic adrenogenital disorder

Excludes 2

Official

No Excludes 2 notes are included in this display for E25.8. Check the code and parent instructions in the Code Book.

Related Codes

Official
E25.0Congenital adrenogenital disorders associated with enzyme deficiencyE25.9Adrenogenital disorder, unspecified

Includes

Official
  • adrenogenital syndromes, virilizing or feminizing, whether acquired or due to adrenal hyperplasia consequent on inborn enzyme defects in hormone synthesisInherited from E25
  • Female adrenal pseudohermaphroditismInherited from E25
  • Female heterosexual precocious pseudopubertyInherited from E25
  • Male isosexual precocious pseudopubertyInherited from E25
  • Male macrogenitosomia praecoxInherited from E25
  • Male sexual precocity with adrenal hyperplasiaInherited from E25
  • Male virilization (female)Inherited from E25

Excludes 1

Official
  • transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89, E20-E35, E25
  • galactorrhea (N64.3)Inherited from E00-E89, E20-E35, E25
  • gynecomastia (N62)Inherited from E00-E89, E20-E35, E25
  • indeterminate sex and pseudohermaphroditism (Q56)Inherited from E00-E89, E20-E35, E25
  • chromosomal abnormalities (Q90-Q99)Inherited from E00-E89, E20-E35, E25

Code First

Official

No Code First sequencing instructions are included in this display for E25.8. Check the code and parent instructions in the Code Book.

Use Additional

Official
  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Code Also

Official

No Code Also instructions are included in this display for E25.8. Check the code and parent instructions in the Code Book.

Buddy Documentation Tip

HCC Buddy guidance
Document whether the condition is acquired versus congenital, the specific clinical presentation (virilization, hirsutism, menstrual dysfunction), adrenal androgen levels (dehydroepiandrosterone sulfate, androstenedione), imaging results, and underlying etiology if identified.

MEAT Support

HCC Buddy guidance
Document whether the condition is acquired versus congenital, the specific clinical presentation (virilization, hirsutism, menstrual dysfunction), adrenal androgen levels (dehydroepiandrosterone sulfate, androstenedione), imaging results, and underlying etiology if identified.

Audit Caution

HCC Buddy guidance
Distinguish between adrenal and ovarian sources of androgen excess, as they require different codes and management.
If the adrenogenital disorder is congenital with documented enzyme deficiency, use E25.0 instead.
Document the acquired nature of the condition clearly.

Common Mistakes

HCC Buddy guidance
E25.0 (congenital adrenogenital disorders with enzyme deficiency), E25.9 (adrenogenital disorder unspecified), E28.1 (androgen excess of ovarian origin rather than adrenal), E27.0 (other adrenocortical overactivity).

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E25.8 an HCC code?

E25.8 is not in the CMS-HCC V28 or V24 community payment model. E25.8 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E25.8 also appears in the HHS-HCC commercial risk model (HCC 030 (HHS-HCC 030 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping.

Code
E25.8
Description
Other adrenogenital disorders
HCC (V28)
No CMS-HCC V28 mapping
RAF reference coefficient
—
Billable
Yes
Payment year
2026

HCC Category Mapping

ESRDHCC 23, Other Significant Endocrine and Metabolic Disorders
Not separately weighted
RxHCCHCC 43, Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders
Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work E25.8 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT review for E25.8

For E25.8, confirm that the documentation supports the diagnosis and meets the applicable coding, encounter, program and payer requirements. MEAT (Monitor, Evaluate, Assess, or Treat) is a review mnemonic, not a universal CMS coding rule.

  • MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
  • EEvaluate: test results, medication response, or physical findings reviewed by the provider
  • AAssess: explicit mention in the assessment or plan with acknowledgment of status
  • TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Coder workflow notes

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What This Code Means

E25.8 is the ICD-10-CM diagnosis code for other adrenogenital disorders. Other types of adrenogenital disorders not classified elsewhere, including acquired forms or atypical presentations of adrenal hormone imbalances. E25.8 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).

E25.8 has no mapping under the CMS-HCC V28 or V24 community payment models. E25.8 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E25.8 also appears in the HHS-HCC commercial risk model (HCC 030 (HHS-HCC 030 adult, RAF varies by metal level)), which is a commercial market model rather than a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.

Use this code only when the specific type of adrenogenital disorder doesn't fit E25.0 or E25.9.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E25.8 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

  • •Use this code only when the specific type of adrenogenital disorder doesn't fit E25.0 or E25.9
  • •Document the underlying cause if it's acquired rather than congenital

Clinical Significance

Other adrenogenital disorders captures acquired forms of adrenal androgen excess or other adrenogenital conditions not caused by congenital enzyme deficiency. These may include androgen-producing adrenal tumors or idiopathic adrenal androgen excess presenting with hirsutism, acne, and menstrual irregularities.

Documentation Requirements

  • ✓Document whether the condition is acquired versus congenital, the specific clinical presentation (virilization, hirsutism, menstrual dysfunction), adrenal androgen levels (dehydroepiandrosterone sulfate, androstenedione), imaging results, and underlying etiology if identified.

Use Additional Code

  • code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Commonly Confused Codes

  • •E25.0 (congenital adrenogenital disorders with enzyme deficiency), E25.9 (adrenogenital disorder unspecified), E28.1 (androgen excess of ovarian origin rather than adrenal), E27.0 (other adrenocortical overactivity).

Child Codes

E25.0Congenital adrenogenital disorders associated with enzyme deficiency
E25.8Other adrenogenital disorders
E25.9Adrenogenital disorder, unspecified

Code Hierarchy

└E25Adrenogenital disorders└E25.8Other adrenogenital disorders
└E25.8Other adrenogenital disorders

Also searched as

  • E25 8
  • E258

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