D43 ICD-10-CM Code: Neoplasm of uncertain behavior of brain and central nervous system
D43 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC coding software
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FY 2026 Apr update / Neoplasms (C00-D49) / Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)
D43
Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidanceNeoplasm of uncertain behavior of brain and central nervous system
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialNo inclusion terms are included in this display for D43. Check the code and parent instructions in the Code Book.
Excludes 2
OfficialNo Excludes 2 notes are included in this display for D43. Check the code and parent instructions in the Code Book.
Related Codes
Includes
OfficialNo Includes notes are included in this display for D43. Check the code and parent instructions in the Code Book.
Excludes 1
Official- neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system (D48.2)
- neoplasms of unspecified behavior (D49.-)Inherited from D37-D48
Code First
OfficialNo Code First sequencing instructions are included in this display for D43. Check the code and parent instructions in the Code Book.
Use Additional
OfficialNo Use Additional Code instructions are included in this display for D43. Check the code and parent instructions in the Code Book.
Code Also
OfficialNo Code Also instructions are included in this display for D43. Check the code and parent instructions in the Code Book.
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
- Code
- D43
- Description
- Neoplasm of uncertain behavior of brain and central nervous system
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- No
- Payment year
- 2026
Coder workflow notes
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What This Code Means
D43 is the ICD-10-CM diagnosis code for neoplasm of uncertain behavior of brain and central nervous system. D43 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (d37-d48).
Header codes like D43 cannot be reported on claims directly; they organize child codes that share clinical context. Coders should select the billable child code that matches the documented presentation and then verify its current source-backed HCC mapping. Do not infer a child code or risk adjustment value from the header alone.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for D43 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Excludes 1, Do NOT code together
- neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system (D48.2)

