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D43 ICD-10-CM Code: Neoplasm of uncertain behavior of brain and central nervous system

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FY 2026 Apr update / Neoplasms (C00-D49) / Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)

D43

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Neoplasm of uncertain behavior of brain and central nervous system

Neoplasm of uncertain behavior of brain and central nervous system

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
D4Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48)
D43Neoplasm of uncertain behavior of brain and central nervous system

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for D43 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for D43 in this effective period.

Related Child Codes

Official
D43.0Neoplasm of uncertain behavior of brain, supratentorial
D43.1Neoplasm of uncertain behavior of brain, infratentorial
D43.2Neoplasm of uncertain behavior of brain, unspecified
D43.3Neoplasm of uncertain behavior of cranial nerves
D43.4Neoplasm of uncertain behavior of spinal cord

Includes

Official

ICD-10-CM does not list Includes notes for D43 in this effective period.

Excludes 1

Official
  • neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system (D48.2)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for D43 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for D43 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for D43 in this effective period.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

What This Code Means

D43 is the ICD-10-CM diagnosis code for neoplasm of uncertain behavior of brain and central nervous system. D43 sits in the ICD-10-CM chapter for neoplasms (c00-d49), within the section covering neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (d37-d48).

Header codes like D43 cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at D43's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D43 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Excludes 1, Do NOT code together

  • neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system (D48.2)

Child Codes

Code Hierarchy

D43Neoplasm of uncertain behavior of brain and central nervous system
D43Neoplasm of uncertain behavior of brain and central nervous system

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