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E78 ICD-10-CM Code: Disorders of lipoprotein metabolism and other lipidemias

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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E78

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Disorders of lipoprotein metabolism and other lipidemias

Disorders of lipoprotein metabolism and other lipidemias

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
E7Metabolic disorders (E70-E88)
E78Disorders of lipoprotein metabolism and other lipidemias

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for E78 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E78 in this effective period.

Related Child Codes

Official
E78.0Pure hypercholesterolemia
E78.1Pure hyperglyceridemia
E78.2Mixed hyperlipidemia
E78.3Hyperchylomicronemia
E78.4Other hyperlipidemia

Includes

Official

ICD-10-CM does not list Includes notes for E78 in this effective period.

Excludes 1

Official
  • sphingolipidosis (E75.0-E75.3)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E78 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E78 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E78 in this effective period.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

What This Code Means

E78 is the ICD-10-CM diagnosis code for disorders of lipoprotein metabolism and other lipidemias. E78 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

Header codes like E78 cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at E78's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E78 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Excludes 1, Do NOT code together

Child Codes

Code Hierarchy

E78Disorders of lipoprotein metabolism and other lipidemias
E78Disorders of lipoprotein metabolism and other lipidemias

More on E78

Referenced in blog posts

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