FY2027 ICD-10-CM reference
E78.2: Mixed hyperlipidemia
By the HCC Buddy Coding Team
The official ICD-10-CM descriptor is Mixed hyperlipidemia. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Billable code. Verified against the official FY2027 order file.
FY2027 Tabular instructions
Instructions below include applicable chapter, section and parent-code notes. Each note identifies where it appears in the official source.
Instructional note
All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: E00-E89 (chapter, inherited).
Excludes1
transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Source: E00-E89 (chapter, inherited).
Excludes1
androgen insensitivity syndrome (E34.5-)
Source: E70-E88 (section, inherited).
Excludes1
congenital adrenal hyperplasia (E25.0)
Source: E70-E88 (section, inherited).
Excludes1
hemolytic anemias attributable to enzyme disorders (D55.-)
Source: E70-E88 (section, inherited).
Excludes1
Marfan syndrome (Q87.4-)
Source: E70-E88 (section, inherited).
Excludes1
5-alpha-reductase deficiency (E29.1)
Source: E70-E88 (section, inherited).
Excludes2
Ehlers-Danlos syndromes (Q79.6-)
Source: E70-E88 (section, inherited).
Excludes1
sphingolipidosis (E75.0-E75.3)
Source: E78 (category, inherited).
Instructional note
Broad- or floating-betalipoproteinemia
Source: E78.2 (self, direct).
Instructional note
Combined hyperlipidemia NOS
Source: E78.2 (self, direct).
Instructional note
Elevated cholesterol with elevated triglycerides NEC
Source: E78.2 (self, direct).
Instructional note
Fredrickson's hyperlipoproteinemia, type IIb or III
Source: E78.2 (self, direct).
Instructional note
Hyperbetalipoproteinemia with prebetalipoproteinemia
Source: E78.2 (self, direct).
Instructional note
Hypercholesteremia with endogenous hyperglyceridemia
Source: E78.2 (self, direct).
Instructional note
Hyperlipidemia, group C
Source: E78.2 (self, direct).
Instructional note
Tubo-eruptive xanthoma
Source: E78.2 (self, direct).
Instructional note
Xanthoma tuberosum
Source: E78.2 (self, direct).
Excludes1
cerebrotendinous cholesterosis [van Bogaert-Scherer- Epstein] (E75.5)
Source: E78.2 (self, direct).
Excludes1
familial combined hyperlipidemia (E78.49)
Source: E78.2 (self, direct).
Compare the FY2027 additions, removals and billable-status changes
What does E78.2 mean in FY2027?
The official ICD-10-CM descriptor is Mixed hyperlipidemia. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Is E78.2 billable in FY2027?
The FY2027 order file marks E78.2 as billable. Check the complete Tabular instructions and documentation before assigning it.
Does E78.2 map to an HCC?
E78.2 has no CMS-HCC V28 category in the CMS 2027 Initial ICD-10-CM Mappings (payment year 2027, 2026 dates of service). ESRD, RxHCC, PACE and HHS-HCC mappings are still pending verification for FY2027.
Source: CMS FY2027 ICD-10-CM order file. Read the FY2027 Official Guidelines.
Review the FY2026 April edition