E78.2
BillableMixed hyperlipidemia
HCC Category Mapping
RxHCCHCC 47 — Disorders of Fatty-Acid and Lipid Metabolism
0.000What This Code Means
Elevated levels of both cholesterol and triglycerides in the blood, significantly increasing the risk of heart disease and stroke.
Coding Tips
- •Document both cholesterol and triglyceride levels for complete clinical picture
- •Determine if this is familial or acquired; may require additional codes for associated conditions
Clinical Significance
Mixed hyperlipidemia indicates concurrent elevation of both cholesterol and triglycerides, representing a combined atherogenic lipid profile. This is one of the most commonly coded metabolic conditions and is a significant modifiable risk factor for atherosclerotic cardiovascular disease, often requiring multi-drug lipid-lowering therapy.
Documentation Requirements
- ✓Provider diagnosis of mixed or combined hyperlipidemia
- ✓Lipid panel showing both elevated cholesterol (or LDL) AND elevated triglycerides
- ✓Whether familial combined hyperlipidemia or acquired
- ✓Current lipid-lowering therapy and treatment response
- ✓Cardiovascular risk assessment and comorbid conditions (diabetes, hypertension)
- ✓Lifestyle modification plan (diet, exercise)
Excludes 1 — Do NOT code together
Commonly Confused Codes
E78.00 — Pure hypercholesterolemia: use when ONLY cholesterol is elevated, triglycerides normalE78.1 — Pure hyperglyceridemia: use when ONLY triglycerides are elevated, cholesterol normalE78.5 — Hyperlipidemia, unspecified: avoid when the specific pattern (mixed) is documentedE78.49 — Other hyperlipidemia: for atypical patterns not fitting pure or mixed categoriesE78.3 — Hyperchylomicronemia: specific chylomicron disorder, not the same as mixed
Code Hierarchy
└E78Disorders of lipoprotein metabolism and other lipidemias└E78.2Mixed hyperlipidemia
└E78.2Mixed hyperlipidemia