FY2027 ICD-10-CM reference
E22.0: Acromegaly and pituitary gigantism
By the HCC Buddy Coding Team
The official ICD-10-CM descriptor is Acromegaly and pituitary gigantism. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Billable code. Verified against the official FY2027 order file.
FY2027 Tabular instructions
Instructions below include applicable chapter, section and parent-code notes. Each note identifies where it appears in the official source.
Instructional note
All neoplasms, whether functionally active or not, are classified in Chapter 2. Appropriate codes in this chapter (i.e. E05.8, E07.0, E16-E31, E34.-) may be used as additional codes to indicate either functional activity by neoplasms and ectopic endocrine tissue or hyperfunction and hypofunction of endocrine glands associated with neoplasms and other conditions classified elsewhere.
Source: E00-E89 (chapter, inherited).
Excludes1
transitory endocrine and metabolic disorders specific to newborn (P70-P74)
Source: E00-E89 (chapter, inherited).
Excludes1
galactorrhea (N64.3)
Source: E20-E35 (section, inherited).
Excludes1
gynecomastia (N62)
Source: E20-E35 (section, inherited).
Excludes1
Cushing's syndrome (E24.-)
Source: E22 (category, inherited).
Excludes1
Nelson's syndrome (E24.1)
Source: E22 (category, inherited).
Excludes1
overproduction of ACTH not associated with Cushing's disease (E27.0)
Source: E22 (category, inherited).
Excludes1
overproduction of pituitary ACTH (E24.0)
Source: E22 (category, inherited).
Excludes1
overproduction of thyroid-stimulating hormone (E05.8-)
Source: E22 (category, inherited).
Instructional note
Overproduction of growth hormone
Source: E22.0 (self, direct).
Excludes1
constitutional gigantism (E34.4)
Source: E22.0 (self, direct).
Excludes1
constitutional tall stature (E34.4)
Source: E22.0 (self, direct).
Excludes1
increased secretion from endocrine pancreas of growth hormone-releasing hormone (E16.8)
Source: E22.0 (self, direct).
Compare the FY2027 additions, removals and billable-status changes
What does E22.0 mean in FY2027?
The official ICD-10-CM descriptor is Acromegaly and pituitary gigantism. The FY2027 annual edition starts October 1, 2026. Check the edition that applies to the encounter or inpatient discharge, including any April update.
Is E22.0 billable in FY2027?
The FY2027 order file marks E22.0 as billable. Check the complete Tabular instructions and documentation before assigning it.
Does E22.0 map to an HCC?
HCC mapping verification is pending for this edition. No HCC category or RAF coefficient is shown.
Source: CMS FY2027 ICD-10-CM order file. Read the FY2027 Official Guidelines.
Review the FY2026 April edition