Specified Lysosomal Storage Disorders
Under the CMS-HCC V28 risk adjustment model (PY2026 Medicare Advantage), HCC 49 carries a community non-dual aged RAF of 9.256, and 13 payable ICD-10-CM diagnosis codes map to it.
RAF factors
The community factor varies by Medicaid and originally-disabled status; the institutional factor applies to long-term-institutional members. These are the CMS-HCC V28 PY2026 relative factors.
ICD-10-CM codes that map to HCC 49 (13)
Payable diagnosis codes that map to this category under CMS-HCC V28 PY2026. Open any code for its full description, HCC mapping, and coding guidance.
- E74.02Pompe disease
- E75.21Fabry (-Anderson) disease
- E75.22Gaucher disease
- E76.01Hurler's syndrome
- E76.02Hurler-Scheie syndrome
- E76.03Scheie's syndrome
- E76.1Mucopolysaccharidosis, type II
- E76.210Morquio A mucopolysaccharidoses
- E76.211Morquio B mucopolysaccharidoses
- E76.219Morquio mucopolysaccharidoses, unspecified
- E76.22Sanfilippo mucopolysaccharidoses
- E76.29Other mucopolysaccharidoses
- E76.3Mucopolysaccharidosis, unspecified
Frequently asked questions
What is CMS-HCC V28 category 49?
HCC 49 is "Specified Lysosomal Storage Disorders", a payment Hierarchical Condition Category in the CMS-HCC V28 risk adjustment model (100% phase-in for payment year 2026). 13 payable ICD-10-CM codes map to it.
What is the RAF weight for HCC 49?
The community non-dual aged relative factor for CMS-HCC V28 category 49 is 9.256. The exact factor varies by enrollment segment (community Medicaid and originally-disabled status, and institutional); the full segment table is published in the CMS V28 Rate Announcement.
How many ICD-10-CM codes map to HCC 49?
13 payable ICD-10-CM diagnosis codes map to CMS-HCC V28 category 49 (Specified Lysosomal Storage Disorders) for payment year 2026.
Source: CMS published ICD-10-CM mapping file plus CMS-HCC v28 PY2026 model software.