V28 HCC 49
Specified Lysosomal Storage Disorders
Under the CMS-HCC V28 risk adjustment model (PY2026 Medicare Advantage), HCC 49 has a source-labeled community non-dual aged reference coefficient of 9.256, and 13 ICD-10-CM diagnosis codes appear in its official mapping.
RAF factors
The community factor varies by Medicaid and originally-disabled status; the institutional factor applies to long-term-institutional members. These are the CMS-HCC V28 PY2026 relative factors.
These are source-labeled code-level HCC coefficient references, not a full member score. Use the RAF Calculator with complete member context for CMS-HCC V28 PY2026. No score is shown unless every required source and calculation check passes.
ICD-10-CM codes that map to HCC 49 (13)
ICD-10-CM codes in the official mapping for this category under CMS-HCC V28 PY2026. Open any code for its full description and coding guidance.
- E74.02Pompe disease
- E75.21Fabry (-Anderson) disease
- E75.22Gaucher disease
- E76.01Hurler's syndrome
- E76.02Hurler-Scheie syndrome
- E76.03Scheie's syndrome
- E76.1Mucopolysaccharidosis, type II
- E76.210Morquio A mucopolysaccharidoses
- E76.211Morquio B mucopolysaccharidoses
- E76.219Morquio mucopolysaccharidoses, unspecified
- E76.22Sanfilippo mucopolysaccharidoses
- E76.29Other mucopolysaccharidoses
- E76.3Mucopolysaccharidosis, unspecified
Coder workflow notes
Get the V28 mapping + MEAT cheat sheet
A printable reference for HCC 49: representative mapping rows and MEAT reminders. Free, no card.
Free PDF. No card. Unsubscribe anytime.
Frequently asked questions
What is CMS-HCC V28 category 49?
HCC 49 is "Specified Lysosomal Storage Disorders", a Hierarchical Condition Category in the CMS-HCC V28 risk adjustment model (100% phase-in for payment year 2026). 13 ICD-10-CM codes appear in its official mapping.
What reference coefficient is published for HCC 49?
The source-labeled community non-dual aged reference coefficient for CMS-HCC V28 category 49 is 9.256. The exact coefficient varies by enrollment segment (community Medicaid and originally-disabled status, and institutional); the full segment table is published in the CMS V28 model files.
How many ICD-10-CM codes map to HCC 49?
13 ICD-10-CM diagnosis codes appear in the official mapping for CMS-HCC V28 category 49 (Specified Lysosomal Storage Disorders) for payment year 2026.
Related references
Sources
CMS ICD-10-CM order-file billability plus the published mapping and CMS-HCC V28 PY2026 model software. CMS-HCC V28 model published at CMS.gov Risk Adjustors; ICD-10-CM member codes from the CMS ICD-10-CM code set.
Verified current to CMS-HCC V28, payment year 2026 — last reviewed May 30, 2026.