C00-D491210 V28 risk-adjusting codes
Neoplasms
ICD-10-CM Chapter 2 (C00-D49) in the FY2026 code set. 1210 codes in this chapter map to a CMS-HCC V28 payment category, across 7 HCC categories.
CMS-HCC V28 categories in this chapter (7)
Open any category for its full member-code list, RAF, and hierarchy.
- HCC 21 Lymphoma and Other Cancers463
- HCC 20 Lung and Other Severe Cancers233
- HCC 23 Prostate, Breast, and Other Cancers and Tumors223
- HCC 22 Bladder, Colorectal, and Other Cancers126
- HCC 17 Cancer Metastatic to Lung, Liver, Brain, and Other Organs; Acute Myeloid Leukemia Except Promyelocytic72
- HCC 19 Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers67
- HCC 18 Cancer Metastatic to Bone, Other and Unspecified Metastatic Cancer; Acute Leukemia Except Myeloid26
Risk-adjusting ICD-10-CM codes (showing 300 of 1210)
Codes in this chapter that map to a CMS-HCC V28 payment category. Open any code for its full detail.
- C01Malignant neoplasm of base of tongue
- C02.0Malignant neoplasm of dorsal surface of tongue
- C02.1Malignant neoplasm of border of tongue
- C02.2Malignant neoplasm of ventral surface of tongue
- C02.3Malignant neoplasm of anterior two-thirds of tongue, part unspecified
- C02.4Malignant neoplasm of lingual tonsil
- C02.8Malignant neoplasm of overlapping sites of tongue
- C02.9Malignant neoplasm of tongue, unspecified
- C03.0Malignant neoplasm of upper gum
- C03.1Malignant neoplasm of lower gum
- C03.9Malignant neoplasm of gum, unspecified
- C04.0Malignant neoplasm of anterior floor of mouth
- C04.1Malignant neoplasm of lateral floor of mouth
- C04.8Malignant neoplasm of overlapping sites of floor of mouth
- C04.9Malignant neoplasm of floor of mouth, unspecified
- C05.0Malignant neoplasm of hard palate
- C05.1Malignant neoplasm of soft palate
- C05.2Malignant neoplasm of uvula
- C05.8Malignant neoplasm of overlapping sites of palate
- C05.9Malignant neoplasm of palate, unspecified
- C06.0Malignant neoplasm of cheek mucosa
- C06.1Malignant neoplasm of vestibule of mouth
- C06.2Malignant neoplasm of retromolar area
- C06.80Malignant neoplasm of overlapping sites of unspecified parts of mouth
- C06.89Malignant neoplasm of overlapping sites of other parts of mouth
- C06.9Malignant neoplasm of mouth, unspecified
- C07Malignant neoplasm of parotid gland
- C08.0Malignant neoplasm of submandibular gland
- C08.1Malignant neoplasm of sublingual gland
- C08.9Malignant neoplasm of major salivary gland, unspecified
- C09.0Malignant neoplasm of tonsillar fossa
- C09.1Malignant neoplasm of tonsillar pillar (anterior) (posterior)
- C09.8Malignant neoplasm of overlapping sites of tonsil
- C09.9Malignant neoplasm of tonsil, unspecified
- C10.0Malignant neoplasm of vallecula
- C10.1Malignant neoplasm of anterior surface of epiglottis
- C10.2Malignant neoplasm of lateral wall of oropharynx
- C10.3Malignant neoplasm of posterior wall of oropharynx
- C10.4Malignant neoplasm of branchial cleft
- C10.8Malignant neoplasm of overlapping sites of oropharynx
- C10.9Malignant neoplasm of oropharynx, unspecified
- C11.0Malignant neoplasm of superior wall of nasopharynx
- C11.1Malignant neoplasm of posterior wall of nasopharynx
- C11.2Malignant neoplasm of lateral wall of nasopharynx
- C11.3Malignant neoplasm of anterior wall of nasopharynx
- C11.8Malignant neoplasm of overlapping sites of nasopharynx
- C11.9Malignant neoplasm of nasopharynx, unspecified
- C12Malignant neoplasm of pyriform sinus
- C13.0Malignant neoplasm of postcricoid region
- C13.1Malignant neoplasm of aryepiglottic fold, hypopharyngeal aspect
- C13.2Malignant neoplasm of posterior wall of hypopharynx
- C13.8Malignant neoplasm of overlapping sites of hypopharynx
- C13.9Malignant neoplasm of hypopharynx, unspecified
- C14.0Malignant neoplasm of pharynx, unspecified
- C14.2Malignant neoplasm of Waldeyer's ring
- C14.8Malignant neoplasm of overlapping sites of lip, oral cavity and pharynx
- C15.3Malignant neoplasm of upper third of esophagus
- C15.4Malignant neoplasm of middle third of esophagus
- C15.5Malignant neoplasm of lower third of esophagus
- C15.8Malignant neoplasm of overlapping sites of esophagus
- C15.9Malignant neoplasm of esophagus, unspecified
- C16.0Malignant neoplasm of cardia
- C16.1Malignant neoplasm of fundus of stomach
- C16.2Malignant neoplasm of body of stomach
- C16.3Malignant neoplasm of pyloric antrum
- C16.4Malignant neoplasm of pylorus
- C16.5Malignant neoplasm of lesser curvature of stomach, unspecified
- C16.6Malignant neoplasm of greater curvature of stomach, unspecified
- C16.8Malignant neoplasm of overlapping sites of stomach
- C16.9Malignant neoplasm of stomach, unspecified
- C17.0Malignant neoplasm of duodenum
- C17.1Malignant neoplasm of jejunum
- C17.2Malignant neoplasm of ileum
- C17.3Meckel's diverticulum, malignant
- C17.8Malignant neoplasm of overlapping sites of small intestine
- C17.9Malignant neoplasm of small intestine, unspecified
- C18.0Malignant neoplasm of cecum
- C18.1Malignant neoplasm of appendix
- C18.2Malignant neoplasm of ascending colon
- C18.3Malignant neoplasm of hepatic flexure
- C18.4Malignant neoplasm of transverse colon
- C18.5Malignant neoplasm of splenic flexure
- C18.6Malignant neoplasm of descending colon
- C18.7Malignant neoplasm of sigmoid colon
- C18.8Malignant neoplasm of overlapping sites of colon
- C18.9Malignant neoplasm of colon, unspecified
- C19Malignant neoplasm of rectosigmoid junction
- C20Malignant neoplasm of rectum
- C21.0Malignant neoplasm of anus, unspecified
- C21.1Malignant neoplasm of anal canal
- C21.2Malignant neoplasm of cloacogenic zone
- C21.8Malignant neoplasm of overlapping sites of rectum, anus and anal canal
- C22.0Liver cell carcinoma
- C22.1Intrahepatic bile duct carcinoma
- C22.2Hepatoblastoma
- C22.3Angiosarcoma of liver
- C22.4Other sarcomas of liver
- C22.7Other specified carcinomas of liver
- C22.8Malignant neoplasm of liver, primary, unspecified as to type
- C22.9Malignant neoplasm of liver, not specified as primary or secondary
- C23Malignant neoplasm of gallbladder
- C24.0Malignant neoplasm of extrahepatic bile duct
- C24.1Malignant neoplasm of ampulla of Vater
- C24.8Malignant neoplasm of overlapping sites of biliary tract
- C24.9Malignant neoplasm of biliary tract, unspecified
- C25.0Malignant neoplasm of head of pancreas
- C25.1Malignant neoplasm of body of pancreas
- C25.2Malignant neoplasm of tail of pancreas
- C25.3Malignant neoplasm of pancreatic duct
- C25.4Malignant neoplasm of endocrine pancreas
- C25.7Malignant neoplasm of other parts of pancreas
- C25.8Malignant neoplasm of overlapping sites of pancreas
- C25.9Malignant neoplasm of pancreas, unspecified
- C26.0Malignant neoplasm of intestinal tract, part unspecified
- C26.1Malignant neoplasm of spleen
- C26.9Malignant neoplasm of ill-defined sites within the digestive system
- C30.0Malignant neoplasm of nasal cavity
- C30.1Malignant neoplasm of middle ear
- C31.0Malignant neoplasm of maxillary sinus
- C31.1Malignant neoplasm of ethmoidal sinus
- C31.2Malignant neoplasm of frontal sinus
- C31.3Malignant neoplasm of sphenoid sinus
- C31.8Malignant neoplasm of overlapping sites of accessory sinuses
- C31.9Malignant neoplasm of accessory sinus, unspecified
- C32.0Malignant neoplasm of glottis
- C32.1Malignant neoplasm of supraglottis
- C32.2Malignant neoplasm of subglottis
- C32.3Malignant neoplasm of laryngeal cartilage
- C32.8Malignant neoplasm of overlapping sites of larynx
- C32.9Malignant neoplasm of larynx, unspecified
- C33Malignant neoplasm of trachea
- C34.00Malignant neoplasm of unspecified main bronchus
- C34.01Malignant neoplasm of right main bronchus
- C34.02Malignant neoplasm of left main bronchus
- C34.10Malignant neoplasm of upper lobe, unspecified bronchus or lung
- C34.11Malignant neoplasm of upper lobe, right bronchus or lung
- C34.12Malignant neoplasm of upper lobe, left bronchus or lung
- C34.2Malignant neoplasm of middle lobe, bronchus or lung
- C34.30Malignant neoplasm of lower lobe, unspecified bronchus or lung
- C34.31Malignant neoplasm of lower lobe, right bronchus or lung
- C34.32Malignant neoplasm of lower lobe, left bronchus or lung
- C34.80Malignant neoplasm of overlapping sites of unspecified bronchus and lung
- C34.81Malignant neoplasm of overlapping sites of right bronchus and lung
- C34.82Malignant neoplasm of overlapping sites of left bronchus and lung
- C34.90Malignant neoplasm of unspecified part of unspecified bronchus or lung
- C34.91Malignant neoplasm of unspecified part of right bronchus or lung
- C34.92Malignant neoplasm of unspecified part of left bronchus or lung
- C37Malignant neoplasm of thymus
- C38.0Malignant neoplasm of heart
- C38.1Malignant neoplasm of anterior mediastinum
- C38.2Malignant neoplasm of posterior mediastinum
- C38.3Malignant neoplasm of mediastinum, part unspecified
- C38.4Malignant neoplasm of pleura
- C38.8Malignant neoplasm of overlapping sites of heart, mediastinum and pleura
- C39.0Malignant neoplasm of upper respiratory tract, part unspecified
- C39.9Malignant neoplasm of lower respiratory tract, part unspecified
- C40.00Malignant neoplasm of scapula and long bones of unspecified upper limb
- C40.01Malignant neoplasm of scapula and long bones of right upper limb
- C40.02Malignant neoplasm of scapula and long bones of left upper limb
- C40.10Malignant neoplasm of short bones of unspecified upper limb
- C40.11Malignant neoplasm of short bones of right upper limb
- C40.12Malignant neoplasm of short bones of left upper limb
- C40.20Malignant neoplasm of long bones of unspecified lower limb
- C40.21Malignant neoplasm of long bones of right lower limb
- C40.22Malignant neoplasm of long bones of left lower limb
- C40.30Malignant neoplasm of short bones of unspecified lower limb
- C40.31Malignant neoplasm of short bones of right lower limb
- C40.32Malignant neoplasm of short bones of left lower limb
- C40.80Malignant neoplasm of overlapping sites of bone and articular cartilage of unspecified limb
- C40.81Malignant neoplasm of overlapping sites of bone and articular cartilage of right limb
- C40.82Malignant neoplasm of overlapping sites of bone and articular cartilage of left limb
- C40.90Malignant neoplasm of unspecified bones and articular cartilage of unspecified limb
- C40.91Malignant neoplasm of unspecified bones and articular cartilage of right limb
- C40.92Malignant neoplasm of unspecified bones and articular cartilage of left limb
- C41.0Malignant neoplasm of bones of skull and face
- C41.1Malignant neoplasm of mandible
- C41.2Malignant neoplasm of vertebral column
- C41.3Malignant neoplasm of ribs, sternum and clavicle
- C41.4Malignant neoplasm of pelvic bones, sacrum and coccyx
- C41.9Malignant neoplasm of bone and articular cartilage, unspecified
- C43.0Malignant melanoma of lip
- C43.10Malignant melanoma of unspecified eyelid, including canthus
- C43.111Malignant melanoma of right upper eyelid, including canthus
- C43.112Malignant melanoma of right lower eyelid, including canthus
- C43.121Malignant melanoma of left upper eyelid, including canthus
- C43.122Malignant melanoma of left lower eyelid, including canthus
- C43.20Malignant melanoma of unspecified ear and external auricular canal
- C43.21Malignant melanoma of right ear and external auricular canal
- C43.22Malignant melanoma of left ear and external auricular canal
- C43.30Malignant melanoma of unspecified part of face
- C43.31Malignant melanoma of nose
- C43.39Malignant melanoma of other parts of face
- C43.4Malignant melanoma of scalp and neck
- C43.51Malignant melanoma of anal skin
- C43.52Malignant melanoma of skin of breast
- C43.59Malignant melanoma of other part of trunk
- C43.60Malignant melanoma of unspecified upper limb, including shoulder
- C43.61Malignant melanoma of right upper limb, including shoulder
- C43.62Malignant melanoma of left upper limb, including shoulder
- C43.70Malignant melanoma of unspecified lower limb, including hip
- C43.71Malignant melanoma of right lower limb, including hip
- C43.72Malignant melanoma of left lower limb, including hip
- C43.8Malignant melanoma of overlapping sites of skin
- C43.9Malignant melanoma of skin, unspecified
- C45.0Mesothelioma of pleura
- C45.1Mesothelioma of peritoneum
- C45.2Mesothelioma of pericardium
- C45.7Mesothelioma of other sites
- C45.9Mesothelioma, unspecified
- C46.0Kaposi's sarcoma of skin
- C46.1Kaposi's sarcoma of soft tissue
- C46.2Kaposi's sarcoma of palate
- C46.3Kaposi's sarcoma of lymph nodes
- C46.4Kaposi's sarcoma of gastrointestinal sites
- C46.50Kaposi's sarcoma of unspecified lung
- C46.51Kaposi's sarcoma of right lung
- C46.52Kaposi's sarcoma of left lung
- C46.7Kaposi's sarcoma of other sites
- C46.9Kaposi's sarcoma, unspecified
- C47.0Malignant neoplasm of peripheral nerves of head, face and neck
- C47.10Malignant neoplasm of peripheral nerves of unspecified upper limb, including shoulder
- C47.11Malignant neoplasm of peripheral nerves of right upper limb, including shoulder
- C47.12Malignant neoplasm of peripheral nerves of left upper limb, including shoulder
- C47.20Malignant neoplasm of peripheral nerves of unspecified lower limb, including hip
- C47.21Malignant neoplasm of peripheral nerves of right lower limb, including hip
- C47.22Malignant neoplasm of peripheral nerves of left lower limb, including hip
- C47.3Malignant neoplasm of peripheral nerves of thorax
- C47.4Malignant neoplasm of peripheral nerves of abdomen
- C47.5Malignant neoplasm of peripheral nerves of pelvis
- C47.6Malignant neoplasm of peripheral nerves of trunk, unspecified
- C47.8Malignant neoplasm of overlapping sites of peripheral nerves and autonomic nervous system
- C47.9Malignant neoplasm of peripheral nerves and autonomic nervous system, unspecified
- C48.0Malignant neoplasm of retroperitoneum
- C48.1Malignant neoplasm of specified parts of peritoneum
- C48.2Malignant neoplasm of peritoneum, unspecified
- C48.8Malignant neoplasm of overlapping sites of retroperitoneum and peritoneum
- C49.0Malignant neoplasm of connective and soft tissue of head, face and neck
- C49.10Malignant neoplasm of connective and soft tissue of unspecified upper limb, including shoulder
- C49.11Malignant neoplasm of connective and soft tissue of right upper limb, including shoulder
- C49.12Malignant neoplasm of connective and soft tissue of left upper limb, including shoulder
- C49.20Malignant neoplasm of connective and soft tissue of unspecified lower limb, including hip
- C49.21Malignant neoplasm of connective and soft tissue of right lower limb, including hip
- C49.22Malignant neoplasm of connective and soft tissue of left lower limb, including hip
- C49.3Malignant neoplasm of connective and soft tissue of thorax
- C49.4Malignant neoplasm of connective and soft tissue of abdomen
- C49.5Malignant neoplasm of connective and soft tissue of pelvis
- C49.6Malignant neoplasm of connective and soft tissue of trunk, unspecified
- C49.8Malignant neoplasm of overlapping sites of connective and soft tissue
- C49.9Malignant neoplasm of connective and soft tissue, unspecified
- C49.A0Gastrointestinal stromal tumor, unspecified site
- C49.A1Gastrointestinal stromal tumor of esophagus
- C49.A2Gastrointestinal stromal tumor of stomach
- C49.A3Gastrointestinal stromal tumor of small intestine
- C49.A4Gastrointestinal stromal tumor of large intestine
- C49.A5Gastrointestinal stromal tumor of rectum
- C49.A9Gastrointestinal stromal tumor of other sites
- C4A.0Merkel cell carcinoma of lip
- C4A.10Merkel cell carcinoma of unspecified eyelid, including canthus
- C4A.111Merkel cell carcinoma of right upper eyelid, including canthus
- C4A.112Merkel cell carcinoma of right lower eyelid, including canthus
- C4A.121Merkel cell carcinoma of left upper eyelid, including canthus
- C4A.122Merkel cell carcinoma of left lower eyelid, including canthus
- C4A.20Merkel cell carcinoma of unspecified ear and external auricular canal
- C4A.21Merkel cell carcinoma of right ear and external auricular canal
- C4A.22Merkel cell carcinoma of left ear and external auricular canal
- C4A.30Merkel cell carcinoma of unspecified part of face
- C4A.31Merkel cell carcinoma of nose
- C4A.39Merkel cell carcinoma of other parts of face
- C4A.4Merkel cell carcinoma of scalp and neck
- C4A.51Merkel cell carcinoma of anal skin
- C4A.52Merkel cell carcinoma of skin of breast
- C4A.59Merkel cell carcinoma of other part of trunk
- C4A.60Merkel cell carcinoma of unspecified upper limb, including shoulder
- C4A.61Merkel cell carcinoma of right upper limb, including shoulder
- C4A.62Merkel cell carcinoma of left upper limb, including shoulder
- C4A.70Merkel cell carcinoma of unspecified lower limb, including hip
- C4A.71Merkel cell carcinoma of right lower limb, including hip
- C4A.72Merkel cell carcinoma of left lower limb, including hip
- C4A.8Merkel cell carcinoma of overlapping sites
- C4A.9Merkel cell carcinoma, unspecified
- C50.011Malignant neoplasm of nipple and areola, right female breast
- C50.012Malignant neoplasm of nipple and areola, left female breast
- C50.019Malignant neoplasm of nipple and areola, unspecified female breast
- C50.021Malignant neoplasm of nipple and areola, right male breast
- C50.022Malignant neoplasm of nipple and areola, left male breast
- C50.029Malignant neoplasm of nipple and areola, unspecified male breast
- C50.111Malignant neoplasm of central portion of right female breast
- C50.112Malignant neoplasm of central portion of left female breast
- C50.119Malignant neoplasm of central portion of unspecified female breast
- C50.121Malignant neoplasm of central portion of right male breast
- C50.122Malignant neoplasm of central portion of left male breast
- C50.129Malignant neoplasm of central portion of unspecified male breast
- C50.211Malignant neoplasm of upper-inner quadrant of right female breast
- C50.212Malignant neoplasm of upper-inner quadrant of left female breast
- C50.219Malignant neoplasm of upper-inner quadrant of unspecified female breast
- C50.221Malignant neoplasm of upper-inner quadrant of right male breast
- C50.222Malignant neoplasm of upper-inner quadrant of left male breast
- C50.229Malignant neoplasm of upper-inner quadrant of unspecified male breast
- C50.311Malignant neoplasm of lower-inner quadrant of right female breast
- C50.312Malignant neoplasm of lower-inner quadrant of left female breast
Frequently asked questions
How many ICD-10-CM codes in Neoplasms risk-adjust under CMS-HCC V28?
1210 ICD-10-CM codes in the C00-D49 chapter (Neoplasms) map to a CMS-HCC V28 payment category for payment year 2026.
Which CMS-HCC V28 categories do C00-D49 codes map to?
Codes in this chapter map to 7 distinct CMS-HCC V28 categories, most commonly HCC 21 (Lymphoma and Other Cancers), HCC 20 (Lung and Other Severe Cancers), HCC 23 (Prostate, Breast, and Other Cancers and Tumors).
What ICD-10-CM chapter is C00-D49?
C00-D49 is ICD-10-CM Chapter 2, Neoplasms, in the FY2026 code set.
Source: FY2026 ICD-10-CM Tabular (CDC/NCHS) and the CMS-HCC v28 PY2026 mapping file.