Question 1

What is ICD-10 code D52.1?

Accepted Answer

D52.1 is the ICD-10-CM diagnosis code for drug-induced folate deficiency anemia. Anemia caused by medications that interfere with the body's ability to use or absorb folate, leading to low red blood cell production. D52.1 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering nutritional anemias (d50-d53).

D52.1 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.

Always identify and code the causative medication using the appropriate drug code.

Question 2

Is D52.1 an HCC code?

Accepted Answer

No. D52.1 is a billable ICD-10-CM code but does not map to any payment HCC category under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can still be reported on Medicare Advantage encounter data submissions, but it does not contribute to the beneficiary's Risk Adjustment Factor (RAF) score and therefore does not affect the risk-adjusted capitation payment to the plan. V28 reached 100% phase-in for payment year 2026.

Question 3

Is D52.1 billable?

Accepted Answer

Yes. D52.1 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. D52.1 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Question 4

What is the V28 vs V24 difference for D52.1?

Accepted Answer

D52.1 does not map to a payment HCC under either the CMS-HCC V28 risk adjustment model or the older V24 model. V28 reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition. Because neither community model rewards D52.1 with a risk adjustment factor, it contributes zero to a Medicare Advantage beneficiary's V28/V24 community RAF score in either version. Coders should check whether provider documentation supports a more specific child code that does map to a community payment HCC.

Question 5

What should coders know when reporting D52.1?

Accepted Answer

Always identify and code the causative medication using the appropriate drug code Document which medication is causing the folate deficiency (e.g., methotrexate, trimethoprim, phenytoin)

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D52.1

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D52.1 ICD-10-CM Code: Drug-induced folate deficiency anemia

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D52.1

Is D52.1 an HCC code?

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What This Code Means

Coding Tips

Use Additional Code

Child Codes

Code Hierarchy

Work D52.1 in HCC Buddy