Question 1

What is ICD-10 code Z15.81?

Accepted Answer

Z15.81 is the ICD-10-CM diagnosis code for genetic susceptibility to multiple endocrine neoplasia [men]. A person has inherited genetic factors that increase their risk of developing multiple endocrine neoplasia (MEN), a condition where tumors develop in multiple hormone-producing glands. Z15.81 sits in the ICD-10-CM chapter for factors influencing health status and contact with health services (z00-z99), within the section covering genetic carrier and genetic susceptibility to disease (z14-z15).

Z15.81 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.

Specify which MEN syndrome type (MEN1, MEN2A, MEN2B) in the documentation when available.

Question 2

Is Z15.81 an HCC code?

Accepted Answer

No. Z15.81 is a billable ICD-10-CM code but does not map to any payment HCC category under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can still be reported on Medicare Advantage encounter data submissions, but it does not contribute to the beneficiary's Risk Adjustment Factor (RAF) score and therefore does not affect the risk-adjusted capitation payment to the plan. V28 reached 100% phase-in for payment year 2026.

Question 3

Is Z15.81 billable?

Accepted Answer

Yes. Z15.81 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. Z15.81 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Question 4

What is the V28 vs V24 difference for Z15.81?

Accepted Answer

Z15.81 does not map to a payment HCC under either the CMS-HCC V28 risk adjustment model or the older V24 model. V28 reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition. Because neither model rewards Z15.81 with a risk adjustment factor, it contributes zero to a Medicare Advantage beneficiary's RAF score in either version. Coders should check whether provider documentation supports a more specific child code that does map to a payment HCC.

Question 5

What should coders know when reporting Z15.81?

Accepted Answer

Specify which MEN syndrome type (MEN1, MEN2A, MEN2B) in the documentation when available This code is for genetic susceptibility; use C-codes if the patient has developed actual neoplasms

HCC Buddy Code Card

Z15.81

Is Z15.81 an HCC code?

What This Code Means

Coding Tips

Excludes 1, Do NOT code together

Child Codes

Code Hierarchy

Open Z15.81 in the Interactive Encoder

Z15.81 ICD-10-CM Code: Genetic susceptibility to multiple endocrine neoplasia [MEN]

HCC Buddy Code Card

Z15.81

Is Z15.81 an HCC code?

What This Code Means

Coding Tips

Excludes 1, Do NOT code together

Child Codes

Code Hierarchy

Open Z15.81 in the Interactive Encoder