What is ICD-10 code E83.825?

E83.825 is the ICD-10-CM diagnosis code for CD73 deficiency causing arterial calcification. A rare genetic disorder caused by CD73 enzyme deficiency that results in abnormal calcium deposits in arteries and other tissues. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E83.825 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E83.825 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E83.825 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E83.825 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Which HCC does E83.825 map to under V28?

E83.825 has no payable CMS-HCC V28 mapping in the final FY2026 CMS file.

What RAF reference is published for E83.825?

E83.825 has no V28 reference coefficient because the final FY2026 source verifies no payable V28 mapping.

What is the V28 vs V24 difference for E83.825?

E83.825 has verified no payable V28 mapping in the final FY2026 source. Select a historical effective period before making any V24 comparison.

2026 ICD-10-CM E83.825: CD73 deficiency causing arterial

E83.825 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools

ICD-10-CM Code View

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Code lookupE83.825Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E83.825

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

CD73 deficiency causing arterial calcification

A rare genetic disorder caused by CD73 enzyme deficiency that results in abnormal calcium deposits in arteries and other tissues.

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Historical

Not used for standard CY2026 Medicare Advantage payment. Select a historical period to review V24.

Not used for CY2026 payment

ACA/HHS

N/A

—

Not risk-adjusted for this model/period.

Not mapped

ESRD/PACE

N/A

—

Not risk-adjusted for this model/period.

Not mapped

RXHCC

Mapped

HCC 43

Pituitary, Adrenal Gland, and...

Code-level coefficient reference

Code Book Path

Official

E83.8Other disorders of mineral metabolism

E83.82Disorders of pyrophosphate metabolism

E83.825CD73 deficiency causing arterial calcification

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for E83.825 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E83.825 in this effective period.

Related Child Codes

Official

E83.820Generalized arterial calcification of infancy with unspecified genetic causality

E83.821ENPP1 deficiency causing generalized arterial calcification of infancy

E83.822ENPP1 deficiency causing autosomal recessive hypophosphatemic rickets type 2

E83.823ABCC6 deficiency causing generalized arterial calcification of infancy

E83.824ABCC6 deficiency causing pseudoxanthoma elasticum

Includes

Official

ICD-10-CM does not list Includes notes for E83.825 in this effective period.

Excludes 1

Official

ICD-10-CM does not list Excludes 1 notes for E83.825 in this effective period.

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E83.825 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E83.825 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E83.825 in this effective period.

Buddy Documentation Tip

HCC Buddy guidance

Verify CD73 deficiency through genetic testing and enzyme activity studies in documentation

Note any associated symptoms such as joint pain, hearing loss, or immune dysfunction that may accompany this condition

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E83.825 an HCC code?

E83.825 is not in the CMS-HCC V28 or V24 community payment model. E83.825 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E83.825 also appears in the HHS-HCC commercial risk model (HCC 028 (HHS-HCC 028 child, RAF varies by metal level)), where the result depends on member context and is not a Medicare Advantage payment mapping.

Code: E83.825
Description: CD73 deficiency causing arterial calcification
HCC (V28): No CMS-HCC V28 mapping
RAF reference coefficient: —
Billable: Yes
Payment year: 2026

HCC Category Mapping

RxHCCHCC 43, Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders

Not separately weighted

These are source-labeled model coefficients, not member totals. A category may still be removed by hierarchy or model cleanup rules. Weights are not directly comparable across models: CMS-HCC V28 and V24 use Community, Non-Dual, Aged; ESRD uses the dialysis continuing-enrollee model; RxHCC is the Part D continuing-enrollee, non-low-income, aged weight (a larger scale than CMS-HCC). ACA/HHS has no single weight — it varies by metal level. Actual per-patient RAF contribution depends on member context, hierarchy and cleanup rules, interactions, and the model year used by the payer. V28 is the CMS-HCC model phased in over payment years 2024–2026; V24 remains available for historical review.

Work E83.825 in the Code Book — tabular path, V28 RAF reference, and MEAT checklist →

MEAT Criteria for E83.825

For E83.825 to count as a valid HCC diagnosis in a given encounter, the provider's documentation must show MEAT: Monitor, Evaluate, Assess, or Treat. A diagnosis from a prior year does not carry forward automatically, it has to be re-documented and supported each calendar year.

MMonitor: signs, symptoms, disease progression, or lab trending documented in the note
EEvaluate: test results, medication response, or physical findings reviewed by the provider
AAssess: explicit mention in the assessment or plan with acknowledgment of status
TTreat: medication, referral, procedure, therapy, or counseling tied to the diagnosis

Only one of M/E/A/T is required to support the code, but the documentation must be specific enough to show that the provider actually addressed E83.825 during that encounter, not just copy-forwarded from a problem list.

Coder workflow notes

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What This Code Means

E83.825 is the ICD-10-CM diagnosis code for cd73 deficiency causing arterial calcification. A rare genetic disorder caused by CD73 enzyme deficiency that results in abnormal calcium deposits in arteries and other tissues. E83.825 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

E83.825 has no mapping under the CMS-HCC V28 or V24 community payment models. E83.825 has a separate mapping under the CMS-HCC ESRD model (HCC 23 (Other Significant Endocrine and Metabolic Disorders)) and the Part D RxHCC model (HCC 43 (Pituitary, Adrenal Gland, and Other Endocrine and Metabolic Disorders)); the applicable result needs member context. E83.825 also appears in the HHS-HCC commercial risk model (HCC 028 (HHS-HCC 028 child, RAF varies by metal level)), where the result depends on member context and is not a Medicare Advantage payment mapping. Do not assign V28 risk adjustment value from this page; verify the applicable model and payment year before using this code for risk adjustment.

Verify CD73 deficiency through genetic testing and enzyme activity studies in documentation.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E83.825 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Verify CD73 deficiency through genetic testing and enzyme activity studies in documentation
•Note any associated symptoms such as joint pain, hearing loss, or immune dysfunction that may accompany this condition