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E79 ICD-10-CM Code: Disorders of purine and pyrimidine metabolism

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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Metabolic disorders (E70-E88)

E79

Header CodeICD-10-CMOfficial ICD-10-CMCodebook guidance

Disorders of purine and pyrimidine metabolism

Disorders of purine and pyrimidine metabolism

CMS-HCC V28

0

0

RAF 0

CMS-HCC V24

0

0

RAF 0

ACA/HHS

0

0

RAF 0

ESRD/PACE

0

0

RAF 0

RXHCC

0

0

RAF 0

Code Trumping

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Code Book Path

Official
E7Metabolic disorders (E70-E88)
E79Disorders of purine and pyrimidine metabolism

Inclusion Terms

Official

ICD-10-CM does not list inclusion terms for E79 in this effective period.

Excludes 2

Official

ICD-10-CM does not list Excludes 2 notes for E79 in this effective period.

Related Child Codes

Official
E79.0Hyperuricemia without signs of inflammatory arthritis and tophaceous disease
E79.1Lesch-Nyhan syndrome
E79.2Myoadenylate deaminase deficiency
E79.8Other disorders of purine and pyrimidine metabolism
E79.9Disorder of purine and pyrimidine metabolism, unspecified

Includes

Official

ICD-10-CM does not list Includes notes for E79 in this effective period.

Excludes 1

Official
  • Ataxia-telangiectasia (Q87.19)
  • Bloom's syndrome (Q82.8)
  • Cockayne's syndrome (Q87.19)
  • calculus of kidney (N20.0)
  • combined immunodeficiency disorders (D81.-)

Code First

Official

ICD-10-CM does not list Code First sequencing instructions for E79 in this effective period.

Use Additional

Official

ICD-10-CM does not list Use Additional Code instructions for E79 in this effective period.

Code Also

Official

ICD-10-CM does not list Code Also instructions for E79 in this effective period.

Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.

What This Code Means

E79 is the ICD-10-CM diagnosis code for disorders of purine and pyrimidine metabolism. E79 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering metabolic disorders (e70-e88).

Header codes like E79 cannot be reported on claims directly, they organize child codes that share clinical context but the actual diagnosis must be coded to the highest level of specificity supported by the documentation. Coders should look at E79's child codes and select the one that matches the patient's documented presentation, since payers reject header codes submitted as the primary diagnosis. For risk adjustment workflows, header codes never contribute to a Medicare Advantage member's RAF score on their own; only billable child codes that happen to map to a payment HCC affect risk-adjusted plan payments.

HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E79 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Excludes 1, Do NOT code together

  • Ataxia-telangiectasia (Q87.19)
  • Bloom's syndrome (Q82.8)
  • Cockayne's syndrome (Q87.19)
  • calculus of kidney (N20.0)
  • combined immunodeficiency disorders (D81.-)
  • Fanconi's anemia (D61.09)
  • gout (M1A.-, M10.-)
  • orotaciduric anemia (D53.0)
  • progeria (E34.8)
  • Werner's syndrome (E34.8)
  • xeroderma pigmentosum (Q82.1)

Child Codes

Code Hierarchy

E79Disorders of purine and pyrimidine metabolism
E79Disorders of purine and pyrimidine metabolism

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