D53.0 ICD-10-CM Code: Protein deficiency anemia
HCC Buddy Code Card
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FY 2026 Apr update / Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89) / Nutritional anemias (D50-D53)
D53.0
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceProtein deficiency anemia
A type of anemia caused by insufficient protein intake or absorption, which is needed to produce healthy red blood cells.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- Amino-acid deficiency anemia
- Orotaciduric anemia
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for D53.0 in this effective period.
Related Child Codes
Includes
Official- megaloblastic anemia unresponsive to vitamin B12 or folate therapy
Excludes 1
Official- Lesch-Nyhan syndrome (E79.1)
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for D53.0 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for D53.0 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for D53.0 in this effective period.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is D53.0 an HCC code?
No. D53.0 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
- Code
- D53.0
- Description
- Protein deficiency anemia
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
D53.0 is the ICD-10-CM diagnosis code for protein deficiency anemia. A type of anemia caused by insufficient protein intake or absorption, which is needed to produce healthy red blood cells. D53.0 sits in the ICD-10-CM chapter for diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (d50-d89), within the section covering nutritional anemias (d50-d53).
D53.0 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Ensure protein deficiency is documented and distinguish from other nutritional deficiencies.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for D53.0 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Ensure protein deficiency is documented and distinguish from other nutritional deficiencies
- •Consider coding any underlying malnutrition or malabsorption condition
Excludes 1, Do NOT code together
- Lesch-Nyhan syndrome (E79.1)