E34.322 ICD-10-CM Code: Insulin-like growth factor-1 (IGF-1) resistance
HCC Buddy Code Card
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)
E34.322
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceInsulin-like growth factor-1 (IGF-1) resistance
A condition where the body produces insulin-like growth factor-1 (IGF-1) but the body's cells do not respond properly to it, limiting growth.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- Genetic syndrome with resistance to insulin-like growth factor-1
- Insulin-like growth factor-1 receptor (IGF-1R) defect
- Post-insulin-like growth factor-1 receptor signaling defect
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E34.322 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E34.322 in this effective period.
Excludes 1
OfficialICD-10-CM does not list Excludes 1 notes for E34.322 in this effective period.
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E34.322 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for E34.322 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for E34.322 in this effective period.
Buddy Documentation Tip
Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.
Is E34.322 an HCC code?
No. E34.322 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
E34.322 is the ICD-10-CM diagnosis code for insulin-like growth factor-1 (igf-1) resistance. A condition where the body produces insulin-like growth factor-1 (IGF-1) but the body's cells do not respond properly to it, limiting growth. E34.322 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).
E34.322 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Document normal or elevated IGF-1 levels with poor growth response to distinguish from primary IGF-1 deficiency.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E34.322 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Document normal or elevated IGF-1 levels with poor growth response to distinguish from primary IGF-1 deficiency
- •This represents a receptor or post-receptor signaling problem rather than insufficient hormone production