What is ICD-10 code E34.322?

E34.322 is the ICD-10-CM diagnosis code for Insulin-like growth factor-1 (IGF-1) resistance. A condition where the body produces insulin-like growth factor-1 (IGF-1) but the body's cells do not respond properly to it, limiting growth. It belongs to the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89). E34.322 is a billable code, meaning it can be reported on a claim as a primary or secondary diagnosis when supported by documentation. E34.322 is part of the FY2026 ICD-10-CM code set published by the CMS National Center for Health Statistics and used on Medicare, Medicaid, and commercial claims in the United States.

Yes. E34.322 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. E34.322 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Which HCC does E34.322 map to under V28?

E34.322 has no payable CMS-HCC V28 mapping in the final FY2026 CMS file.

What RAF reference is published for E34.322?

E34.322 has no V28 reference coefficient because the final FY2026 source verifies no payable V28 mapping.

What is the V28 vs V24 difference for E34.322?

E34.322 has verified no payable V28 mapping in the final FY2026 source. Select a historical effective period before making any V24 comparison.

2026 ICD-10-CM E34.322: Insulin-like growth factor-1 (IGF-1)

E34.322 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · HCC Buddy coding tools

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Code lookupE34.322

Effective periodFY2026 Apr Update (Apr 1-Sep 30)

FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)

E34.322

Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidance

Insulin-like growth factor-1 (IGF-1) resistance

A condition where the body produces insulin-like growth factor-1 (IGF-1) but the body's cells do not respond properly to it, limiting growth.

Overview Risk Models Code Book Documentation Audit Notes Edition comparison

CMS-HCC V28

N/A

—

Not risk-adjusted for this model/period.

Not mapped

CMS-HCC V24

Historical

Not used for standard CY2026 Medicare Advantage payment. Select a historical period to review V24.

Not used for CY2026 payment

ACA/HHS

N/A

—

Not risk-adjusted for this model/period.

Not mapped

ESRD/PACE

N/A

—

Not risk-adjusted for this model/period.

Not mapped

RXHCC

N/A

—

Not risk-adjusted for this model/period.

Not mapped

Code Book Path

Official

E34.3Short stature due to endocrine disorder E34.32Genetic causes of short stature E34.322Insulin-like growth factor-1 (IGF-1) resistance

Inclusion Terms

Official

Genetic syndrome with resistance to insulin-like growth factor-1
Insulin-like growth factor-1 receptor (IGF-1R) defect
Post-insulin-like growth factor-1 receptor signaling defect

Excludes 2

Official

No Excludes 2 notes are included in this display for E34.322. Check the code and parent instructions in the Code Book.

Related Codes

Official

E34.321Primary insulin-like growth factor-1 (IGF-1) deficiency E34.328Other genetic causes of short stature E34.329Unspecified genetic causes of short stature

Includes

Official

No Includes notes are included in this display for E34.322. Check the code and parent instructions in the Code Book.

Excludes 1

Official

transitory endocrine and metabolic disorders specific to newborn (P70-P74)Inherited from E00-E89, E20-E35, E34, E34.3
galactorrhea (N64.3)Inherited from E00-E89, E20-E35, E34, E34.3
gynecomastia (N62)Inherited from E00-E89, E20-E35, E34, E34.3
pseudohypoparathyroidism (E20.1)Inherited from E00-E89, E20-E35, E34, E34.3
achondroplastic short stature (Q77.4)Inherited from E00-E89, E20-E35, E34, E34.3
hypochondroplastic short stature (Q77.4)Inherited from E00-E89, E20-E35, E34, E34.3
nutritional short stature (E45)Inherited from E00-E89, E20-E35, E34, E34.3
pituitary short stature (E23.0)Inherited from E00-E89, E20-E35, E34, E34.3
progeria (E34.8)Inherited from E00-E89, E20-E35, E34, E34.3
renal short stature (N25.0)Inherited from E00-E89, E20-E35, E34, E34.3
Russell-Silver syndrome (Q87.19)Inherited from E00-E89, E20-E35, E34, E34.3
short-limbed stature with immunodeficiency (D82.2)Inherited from E00-E89, E20-E35, E34, E34.3
short stature (child) (R62.52)Inherited from E00-E89, E20-E35, E34, E34.3
short stature in specific dysmorphic syndromes - code to syndrome - see Alphabetical IndexInherited from E00-E89, E20-E35, E34, E34.3
short stature NOS (R62.52)Inherited from E00-E89, E20-E35, E34, E34.3

Code First

Official

No Code First sequencing instructions are included in this display for E34.322. Check the code and parent instructions in the Code Book.

Use Additional

Official

No Use Additional Code instructions are included in this display for E34.322. Check the code and parent instructions in the Code Book.

Code Also

Official

No Code Also instructions are included in this display for E34.322. Check the code and parent instructions in the Code Book.

Buddy Documentation Tip

HCC Buddy guidance

Document normal or elevated IGF-1 levels with poor growth response to distinguish from primary IGF-1 deficiency

This represents a receptor or post-receptor signaling problem rather than insufficient hormone production

Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →

Is E34.322 an HCC code?

No. E34.322 is a billable ICD-10-CM code with no mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models.

Code: E34.322
Description: Insulin-like growth factor-1 (IGF-1) resistance
HCC (V28): No CMS-HCC V28 mapping
RAF reference coefficient: —
Billable: Yes
Payment year: 2026

Coder workflow notes

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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).

What This Code Means

E34.322 is the ICD-10-CM diagnosis code for insulin-like growth factor-1 (igf-1) resistance. A condition where the body produces insulin-like growth factor-1 (IGF-1) but the body's cells do not respond properly to it, limiting growth. E34.322 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).

E34.322 is a billable ICD-10-CM code, but the current payload does not show a mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models. Do not assign risk adjustment value from this page when no source-backed mapping is shown; verify the applicable model and payment year.

Document normal or elevated IGF-1 levels with poor growth response to distinguish from primary IGF-1 deficiency.

HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E34.322 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.

Coding Tips

•Document normal or elevated IGF-1 levels with poor growth response to distinguish from primary IGF-1 deficiency
•This represents a receptor or post-receptor signaling problem rather than insufficient hormone production