E34.321 ICD-10-CM Code: Primary insulin-like growth factor-1 (IGF-1) deficiency
E34.321 is not a CMS-HCC payment code. MEAT criteria · RAF Calculator · free HCC coding tools
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)
E34.321
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidancePrimary insulin-like growth factor-1 (IGF-1) deficiency
A condition where the body does not produce enough insulin-like growth factor-1 (IGF-1), a hormone essential for normal growth and development.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
HistoricalHistorical
Not used for CY2026 payment
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- Acid-labile subunit gene (IGFALS) defect
- Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Growth hormone insensitivity syndrome (GHIS)
- Insulin-like growth factor 1 gene (IGF1) defect
- Laron type short stature
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E34.321 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E34.321 in this effective period.
Excludes 1
OfficialICD-10-CM does not list Excludes 1 notes for E34.321 in this effective period.
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E34.321 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for E34.321 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for E34.321 in this effective period.
Buddy Documentation Tip
Current with CMS: FY2026 ICD-10-CM Apr 1 update (effective Apr 1 – Sep 30, 2026) · CMS-HCC V28, 100% phased in for payment year 2026. FY2027 code set already staged for October 1, 2026. How HCC Buddy stays current →
Is E34.321 an HCC code?
No. E34.321 is a billable ICD-10-CM code with no mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models.
- Code
- E34.321
- Description
- Primary insulin-like growth factor-1 (IGF-1) deficiency
- HCC (V28)
- No CMS-HCC V28 mapping
- RAF reference coefficient
- —
- Billable
- Yes
- Payment year
- 2026
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
E34.321 is the ICD-10-CM diagnosis code for primary insulin-like growth factor-1 (igf-1) deficiency. A condition where the body does not produce enough insulin-like growth factor-1 (IGF-1), a hormone essential for normal growth and development. E34.321 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).
E34.321 is a billable ICD-10-CM code, but the current payload does not show a mapping under the CMS-HCC V28 or V24 community payment models, and none under the ESRD, Part D RxHCC, or HHS-HCC models. Do not assign risk adjustment value from this page when no source-backed mapping is shown; verify the applicable model and payment year.
Document IGF-1 levels and growth hormone stimulation test results to support this diagnosis.
HCC Buddy maintains structured V28 and V24 mapping, source-labeled coefficient references, and MEAT documentation criteria for E34.321 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Document IGF-1 levels and growth hormone stimulation test results to support this diagnosis
- •This is a primary deficiency; distinguish from IGF-1 resistance (E34.322) where IGF-1 is produced but not effective