E34.321 ICD-10-CM Code: Primary insulin-like growth factor-1 (IGF-1) deficiency
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FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)
E34.321
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidancePrimary insulin-like growth factor-1 (IGF-1) deficiency
A condition where the body does not produce enough insulin-like growth factor-1 (IGF-1), a hormone essential for normal growth and development.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
Official- Acid-labile subunit gene (IGFALS) defect
- Growth hormone gene 1 (GH1) defect with growth hormone neutralizing antibodies
- Growth hormone insensitivity syndrome (GHIS)
- Insulin-like growth factor 1 gene (IGF1) defect
- Laron type short stature
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E34.321 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E34.321 in this effective period.
Excludes 1
OfficialICD-10-CM does not list Excludes 1 notes for E34.321 in this effective period.
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E34.321 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for E34.321 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for E34.321 in this effective period.
Buddy Documentation Tip
Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.
Is E34.321 an HCC code?
No. E34.321 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
Coder workflow notes
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This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
E34.321 is the ICD-10-CM diagnosis code for primary insulin-like growth factor-1 (igf-1) deficiency. A condition where the body does not produce enough insulin-like growth factor-1 (IGF-1), a hormone essential for normal growth and development. E34.321 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).
E34.321 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Document IGF-1 levels and growth hormone stimulation test results to support this diagnosis.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E34.321 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Document IGF-1 levels and growth hormone stimulation test results to support this diagnosis
- •This is a primary deficiency; distinguish from IGF-1 resistance (E34.322) where IGF-1 is produced but not effective