E28.0 ICD-10-CM Code: Estrogen excess
HCC Buddy Code Card
Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.
FY 2026 Apr update / Endocrine, nutritional and metabolic diseases (E00-E89) / Disorders of other endocrine glands (E20-E35)
E28.0
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceEstrogen excess
This condition occurs when the body produces or is exposed to too much estrogen, a female hormone. It can cause symptoms like breast tenderness, irregular periods, and mood changes.
CMS-HCC V28
N/A—
Not mapped
CMS-HCC V24
N/A—
Not mapped
ACA/HHS
N/A—
Not mapped
ESRD/PACE
N/A—
Not mapped
RXHCC
N/A—
Not mapped
Code Book Path
Inclusion Terms
OfficialICD-10-CM does not list inclusion terms for E28.0 in this effective period.
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for E28.0 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for E28.0 in this effective period.
Excludes 1
Official- isolated gonadotropin deficiency (E23.0)
- postprocedural ovarian failure (E89.4-)
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for E28.0 in this effective period.
Use Additional
Official- code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)
Code Also
OfficialICD-10-CM does not list Code Also instructions for E28.0 in this effective period.
Buddy Documentation Tip
Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.
Is E28.0 an HCC code?
No. E28.0 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
Coder workflow notes
Get the V28 RAF + MEAT cheat sheet
One printable page: confirm a code's V28 HCC status, its RAF weight, and the MEAT your note needs to make it stick. Free, no card.
Free PDF. No card. Unsubscribe anytime.
This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
E28.0 is the ICD-10-CM diagnosis code for estrogen excess. This condition occurs when the body produces or is exposed to too much estrogen, a female hormone. It can cause symptoms like breast tenderness, irregular periods, and mood changes. E28.0 sits in the ICD-10-CM chapter for endocrine, nutritional and metabolic diseases (e00-e89), within the section covering disorders of other endocrine glands (e20-e35).
E28.0 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Verify the underlying cause of estrogen excess (such as ovarian tumors, polycystic ovary syndrome, or medication-induced) and code the etiology separately if documented.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for E28.0 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Verify the underlying cause of estrogen excess (such as ovarian tumors, polycystic ovary syndrome, or medication-induced) and code the etiology separately if documented
- •Ensure this code is not used for normal hormonal fluctuations; it should only be coded when there is documented clinical evidence of pathologically elevated estrogen levels