D58.2

HCC Category Mapping

What This Code Means

A group of inherited blood disorders involving abnormal hemoglobin (the protein that carries oxygen in red blood cells), such as sickle cell disease or thalassemia.

Coding Tips

• •Use additional codes to specify the type of hemoglobinopathy when documented
• •Document any acute complications like vaso-occlusive crises separately

Clinical Significance

Other hemoglobinopathies encompasses a diverse group of inherited disorders of hemoglobin structure or production not classified under sickle-cell disease or thalassemia major categories, including unstable hemoglobin variants, hemoglobins with altered oxygen affinity, and methemoglobinemias. Clinical severity varies widely from asymptomatic carrier states to severe hemolytic anemia depending on the specific hemoglobin variant. Over 1,000 hemoglobin variants have been identified, though only a fraction cause clinically significant disease.

Documentation Requirements

• ✓Document the specific hemoglobin variant by name when identified through hemoglobin electrophoresis, high-performance liquid chromatography, or genetic testing.
• ✓Record baseline hemoglobin levels, evidence of hemolysis if present, and oxygen-carrying capacity.
• ✓Include family history of hemoglobinopathy and any genetic counseling provided.
• ✓Document any complications such as chronic hemolytic anemia, gallstones, or iron overload.

Commonly Confused Codes