Question 1

What is ICD-10 code Z16.33?

Accepted Answer

Z16.33 is the ICD-10-CM diagnosis code for resistance to antiviral drug(s). A condition where viruses have become resistant to antiviral drugs, reducing the effectiveness of treatment options. Z16.33 sits in the ICD-10-CM chapter for factors influencing health status and contact with health services (z00-z99), within the section covering resistance to antimicrobial drugs (z16).

Z16.33 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.

Commonly used for HIV resistance patterns and hepatitis C resistance; ensure the specific viral infection is coded separately.

Question 2

Is Z16.33 an HCC code?

Accepted Answer

No. Z16.33 is a billable ICD-10-CM code but does not map to any payment HCC category under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can still be reported on Medicare Advantage encounter data submissions, but it does not contribute to the beneficiary's Risk Adjustment Factor (RAF) score and therefore does not affect the risk-adjusted capitation payment to the plan. V28 reached 100% phase-in for payment year 2026.

Question 3

Is Z16.33 billable?

Accepted Answer

Yes. Z16.33 is a billable ICD-10-CM code that can be reported on professional and institutional claims as a primary or secondary diagnosis when the provider documentation supports the specific condition described. Billable codes in ICD-10-CM are coded to the highest level of specificity available for the documented diagnosis. Z16.33 is current for fiscal year 2026 and remains in the active CMS ICD-10-CM code set published by the National Center for Health Statistics.

Question 4

What is the V28 vs V24 difference for Z16.33?

Accepted Answer

Z16.33 does not map to a payment HCC under either the CMS-HCC V28 risk adjustment model or the older V24 model. V28 reached 100% phase-in for payment year 2026, replacing V24 which was used during the PY2024–PY2025 transition. Because neither model rewards Z16.33 with a risk adjustment factor, it contributes zero to a Medicare Advantage beneficiary's RAF score in either version. Coders should check whether provider documentation supports a more specific child code that does map to a payment HCC.

Question 5

What should coders know when reporting Z16.33?

Accepted Answer

Commonly used for HIV resistance patterns and hepatitis C resistance; ensure the specific viral infection is coded separately Document which antiviral agents the virus is resistant to for clinical clarity

HCC Buddy Code Card

Z16.33

Is Z16.33 an HCC code?

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Open Z16.33 in the Interactive Encoder

Z16.33 ICD-10-CM Code: Resistance to antiviral drug(s)

HCC Buddy Code Card

Z16.33

Is Z16.33 an HCC code?

What This Code Means

Coding Tips

Child Codes

Code Hierarchy

Open Z16.33 in the Interactive Encoder