Z15.068 ICD-10-CM Code: Genetic susceptibility to other malignant neoplasm of digestive system
HCC Buddy Code Card
Digital ICD-10 code-book layout with official code detail, always-visible risk models, Code Trumping, and Buddy coding guidance.
FY 2026 Apr update / Factors influencing health status and contact with health services (Z00-Z99) / Genetic carrier and genetic susceptibility to disease (Z14-Z15)
Z15.068
Billable / SpecificICD-10-CMOfficial ICD-10-CMCodebook guidanceGenetic susceptibility to other malignant neoplasm of digestive system
A person has inherited genetic factors that increase their risk of developing certain cancers of the digestive system beyond the common types already specified.
CMS-HCC V28
00
RAF 0
CMS-HCC V24
00
RAF 0
ACA/HHS
00
RAF 0
ESRD/PACE
00
RAF 0
RXHCC
00
RAF 0
Code Trumping
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Code Book Path
Inclusion Terms
Official- Genetic susceptibility to biliary tract cancer
- Genetic susceptibility to gastric cancer
- Genetic susceptibility to pancreatic cancer
- Genetic susceptibility to small bowel cancer
Excludes 2
OfficialICD-10-CM does not list Excludes 2 notes for Z15.068 in this effective period.
Related Child Codes
Includes
OfficialICD-10-CM does not list Includes notes for Z15.068 in this effective period.
Excludes 1
OfficialICD-10-CM does not list Excludes 1 notes for Z15.068 in this effective period.
Code First
OfficialICD-10-CM does not list Code First sequencing instructions for Z15.068 in this effective period.
Use Additional
OfficialICD-10-CM does not list Use Additional Code instructions for Z15.068 in this effective period.
Code Also
OfficialICD-10-CM does not list Code Also instructions for Z15.068 in this effective period.
Buddy Documentation Tip
Last updated: FY2026 ICD-10-CM Apr update, Apr 1, 2026 through Sep 30, 2026. CMS-HCC V28 is 100% phased in for payment year 2026.
Is Z15.068 an HCC code?
No. Z15.068 is a billable ICD-10-CM code but does not map to any HCC category in V28, V24, ESRD, or RxHCC.
This code does not map to an HCC category in any model (V28, V24, ESRD, RxHCC).
What This Code Means
Z15.068 is the ICD-10-CM diagnosis code for genetic susceptibility to other malignant neoplasm of digestive system. A person has inherited genetic factors that increase their risk of developing certain cancers of the digestive system beyond the common types already specified. Z15.068 sits in the ICD-10-CM chapter for factors influencing health status and contact with health services (z00-z99), within the section covering genetic carrier and genetic susceptibility to disease (z14-z15).
Z15.068 is a billable ICD-10-CM code but does not map to a payment HCC under the CMS-HCC V28, V24, ESRD, or RxHCC risk adjustment models. It can be reported on Medicare Advantage encounter data submissions but it does not contribute to a beneficiary's RAF score and therefore does not affect risk-adjusted payments to the plan.
Use this code when genetic testing or family history indicates predisposition to digestive cancers not covered by more specific Z15.06 subcodes.
HCC Buddy maintains structured V28 and V24 mapping, RAF weights, and MEAT documentation criteria for Z15.068 sourced directly from the CMS-HCC risk adjustment model files and the CMS ICD-10-CM code set.
Coding Tips
- •Use this code when genetic testing or family history indicates predisposition to digestive cancers not covered by more specific Z15.06 subcodes
- •This is a status code used for risk assessment and preventive care planning, not for an actual cancer diagnosis