M31.11
BillableHematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]
HCC Category Mapping
V28HCC 454 — Graft-Versus-Host Disease and Stem Cell Transplant Complications
0.000V24HCC 186 — Major Organ Transplant or Replacement Status
0.910ESRDHCC 186 — Major Organ Transplant or Replacement Status
0.000RxHCCHCC 395 — Graft-Versus-Host Disease
0.000What This Code Means
A serious complication that can occur after bone marrow or stem cell transplantation, where small blood vessels become blocked by clots.
Coding Tips
- •Always link this code to the transplant procedure code
- •Document the timeframe of onset relative to the HSCT procedure
Clinical Significance
HSCT-associated thrombotic microangiopathy is a serious complication of stem cell transplantation with high mortality risk. This condition requires immediate recognition and aggressive management, as it can lead to multi-organ failure in already immunocompromised transplant recipients.
Documentation Requirements
- ✓Documentation of prior hematopoietic stem cell transplant
- ✓Timeline showing TMA onset post-transplant
- ✓Clinical evidence of microangiopathic hemolytic anemia
- ✓Thrombocytopenia in transplant setting
- ✓Organ dysfunction assessment
- ✓Exclusion of other TMA causes
- ✓GVHD status documentation
- ✓Treatment modifications for transplant setting
Use Additional Code
- code to identify specific organ dysfunction, such as:
- acute kidney failure (N17.-)
- acute respiratory distress syndrome (J80)
- capillary leak syndrome (I78.8)
- diffuse alveolar hemorrhage (R04.89)
- encephalopathy (metabolic) (septic) (G93.41)
- fluid overload, unspecified (E87.70)
- graft versus host disease (D89.81-)
- hemolytic uremic syndrome (D59.3-)
- hepatic failure (K72.-)
- hepatic veno-occlusive disease (K76.5)
- idiopathic interstitial pneumonia (J84.11-)
- sinusoidal obstruction syndrome (K76.5)
Code First
Commonly Confused Codes
M31.10 — Thrombotic microangiopathy, unspecified (when transplant history not coded)T86.01 — Bone marrow transplant rejection (different transplant complication)D89.813 — Graft-versus-host disease, acute (different transplant complication)D59.3 — Hemolytic-uremic syndrome (not transplant-related)Z94.81 — Bone marrow transplant status (status code only)
Code Hierarchy
└M31Other necrotizing vasculopathies└M31.1Thrombotic microangiopathy└M31.11Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]
└M31.11Hematopoietic stem cell transplantation-associated thrombotic microangiopathy [HSCT-TMA]