E23.1

Billable

Drug-induced hypopituitarism

HCC Category Mapping

V24HCC 23 — Other Significant Endocrine and Metabolic Disorders

0.230

ESRDHCC 23 — Other Significant Endocrine and Metabolic Disorders

0.000

RxHCCHCC 43 — Other Significant Endocrine and Metabolic Disorders

0.000

What This Code Means

Insufficient pituitary hormone production caused by medications or drugs that the patient is taking or has taken.

Coding Tips

•Document the specific medication causing hypopituitarism and link it to the condition in the medical record
•Consider coding the adverse effect of the drug separately if appropriate, using the drug-induced code as the primary diagnosis

Clinical Significance

Drug-induced hypopituitarism occurs when medications suppress pituitary function, most commonly seen with chronic opioid use, glucocorticoid therapy, or immune checkpoint inhibitor therapy. Recognition is critical because symptoms like fatigue, weakness, and cognitive changes may be attributed to other causes, delaying appropriate management.

Documentation Requirements

✓Document the specific causative medication, temporal relationship between drug exposure and pituitary dysfunction, affected hormone axes, baseline and follow-up hormone levels, and whether the condition is expected to be reversible upon drug discontinuation.

Use Additional Code

code for adverse effect, if applicable, to identify drug (T36-T50 with fifth or sixth character 5)

Commonly Confused Codes

E23.0 (hypopituitarism not caused by drugs), E89.3 (postprocedural hypopituitarism), T38-T50 (adverse effect codes for the causative drug which should be coded additionally).

Code Hierarchy

└E23Hypofunction and other disorders of the pituitary gland └E23.1Drug-induced hypopituitarism

└E23.1Drug-induced hypopituitarism